Results 101 to 110 of about 2,663,550 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Plug-and-play and coordinated control for bus-connected AC islanded microgrids

, 2017
This paper presents a distributed control architecture for voltage and frequency stabilization in AC islanded microgrids. In the primary control layer, each generation unit is equipped with a local controller acting on the corresponding voltage-source ...
Ferrari-Trecate, Giancarlo, Guerrero, Josep M., Riverso, Stefano, Tucci, Michele, Vasquez, Juan C.   +4 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Distributed generation: definition, benefits and issues [PDF]

This paper starts from the observation that there is a renewed interest in small-scale electricity generation. The authors start with a survey of existing small-scale generation technologies and then move on with a discussion of the major benefits and ...
Dries Haeseldonckx, Guido Pepermans, Johan Driesen   +2 more
core  

Distributed generation [PDF]

, 2005
Hansen, J.C., Lundsager, P., Nielsen, L.H.   +2 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

The Photovoltaic Generation and its Energy Contribution and Demand Shifting at the Center Headquarters of the Federal University of Technology - Paraná - Campus Curitiba

Brazilian Archives of Biology and Technology, 2018
Distributed photovoltaic (PV) generation is characterized by the application of several small power plants in urban centers. This form of energy deserves special mention due to the possibility of installation in existing areas such as roofs and facades ...
Juliana D’Angela Mariano, Jair Urbanetz Junior   +1 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Distributed watermarking for secure control of microgrids under replay attacks

, 2018
The problem of replay attacks in the communication network between Distributed Generation Units (DGUs) of a DC microgrid is examined. The DGUs are regulated through a hierarchical control architecture, and are networked to achieve secondary control ...
Cavraro, Chen, Cheng, Ferrari, Guerrero, Meng, Meng, Miao, Mo, Sandberg, Tucci, Tucci, Zhao   +12 more
core   +1 more source