Results 101 to 110 of about 7,723,373 (378)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Impact of hybrid renewable energy systems on short circuit levels in distribution networks [PDF]

open access: yes, 2014
The effects of the distributed generation can be classified as environmental, technical and economical effects. It is playing a very vital role for improving the voltage profiles in electrical power systems.
Afifi, SN, Darwish, MK
core   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

A new algorithm for allocating multiple distributed generation units based on load centroid concept

open access: yesAlexandria Engineering Journal, 2013
Allocation of distributed generation (DG) units is commonly formulated as a constrained nonlinear optimization problem solved by complex iterative mathematical or heuristic techniques.
A. Elmitwally
doaj   +1 more source

Optimization of the operation of smart rural grids through a novel rnergy management system [PDF]

open access: yes, 2017
The paper proposes an innovative Energy Management System (EMS) that optimizes the grid operation based on economic and technical criteria. The EMS inputs the demand and renewable generation forecasts, electricity prices and the status of the distributed
Díaz González, Francisco   +2 more
core   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

A Fast Fault Detection Scheme for Power Converters In Distributed Generation Systems

open access: yesEletrônica de Potência, 2012
In this paper, a fault detection algorithm based on voltage disturbances is proposed and analyzed. This method observes the voltage characteristics instead of the current amplitude, that is the most common approach in power distribution electrical ...
Gustavo M. S. Azevedo   +3 more
doaj   +1 more source

Active local distribution network management for embedded generation [PDF]

open access: yes, 2005
Traditionally, distribution networks have been operated as passive networks with uni-directional power flows. With the connection of increasing amounts of distributed generation, these networks are becoming active with power flowing in two directions ...
White, Sara
core  

Net solar generation potential from urban rooftops in Los Angeles [PDF]

open access: yes, 2020
Rooftops provide accessible locations for solar energy installations. While rooftop solar arrays can offset in-building electricity needs, they may also stress electric grid operations.
Cheng, D   +6 more
core  

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