Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Distributed generation adverse impact on the distribution networks protection and its mitigation. [PDF]
Heliyon, 2022 Takele H.
europepmc +1 more source
Research on Issues and Policy Evaluative Factors of Implementing Distributed Photovoltaic Power Generation in Frontier Rural Areas of China [PDF]
, 2017 Gang Feng
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Optimal placement of distributed generation based on DISCO's financial benefit with loss and emission reduction using hybrid Jaya-Red Deer optimizer. [PDF]
Electr Eng (Berl), 2023 Lakshmi GVN, Jayalaxmi A, Veeramsetty V.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Learning Observer-Based Sensor Fault-Tolerant Control of Distributed Generation in an Islanded Microgrid for Bus Voltage Stability Enhancement. [PDF]
Sensors (Basel), 2022 Mao J, Yin C, Zhang X, Wu A, Zhang X.
europepmc +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Electromechanical Peak Devices of Distributed Power Generation
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2011 The power world crises (1973, 1979) have demonstrated that mankind entered the expensive energy epoch. More and more attitude is given to power saving problem by including renewable power sources in energy balance of the countries.
S. V. Konstantinova
doaj
Parallel operated hybrid Arithmetic-Salp swarm optimizer for optimal allocation of multiple distributed generation units in distribution networks. [PDF]
PLoS One, 2022 Anjum ZM +4 more
europepmc +1 more source