Results 141 to 150 of about 7,964,343 (399)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Analysis and Optimization of the Impact of Distributed Generation Integration on Distribution Network Loss [PDF]
, 2023 Xiaofeng Zhu +5 more
openalex +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The generation of side force by distributed suction [PDF]
This report provides an approximate analysis of the generation of side force on a cylinder placed horizontal to the flow direction by the application of distributed suction on the rearward side of the cylinder.
Hong, John, Roberts, Leonard
core +1 more source
Distributed watermarking for secure control of microgrids under replay attacks
, 2018 The problem of replay attacks in the communication network between Distributed Generation Units (DGUs) of a DC microgrid is examined. The DGUs are regulated through a hierarchical control architecture, and are networked to achieve secondary control ...
Cavraro +12 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Research on Microgrid Control System with Different DG Types
Dianxin kexue, 2013 According to the grid-connected and islanded operating modes of microgrid and the changeover between them,a control strategy of microgrid with different kinds of DG（distributed generation）was proposed,which monitors the operating states of both microgrid
Litao Wang, Weihua Tian, Baixiang Zheng
doaj +2 more sources