Results 61 to 70 of about 392,453 (267)

Distribution-Independent Reliable Learning

CoRR, 2014
20 ...
Varun Kanade, Justin Thaler
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Navigating rural medical training: mapping the landscape of resident physician wellbeing using critical realist inquiry

Frontiers in Medicine
BackgroundFamily Medicine residents in rural training programs experience a unique set of challenges and rewards, including professional isolation, resource limitations, and increased autonomy.
Grace Perez, Aaron Johnston, Aaron Johnston, Aaron Johnston, Rabiya Jalil, Rabiya Jalil, Benedicta Antepim, Aliya Kassam, Aliya Kassam   +8 more
doaj   +1 more source

Distributed Continual Learning

CoRR
This work studies the intersection of continual and federated learning, in which independent agents face unique tasks in their environments and incrementally develop and share knowledge. We introduce a mathematical framework capturing the essential aspects of distributed continual learning, including agent model and statistical heterogeneity, continual
Long Le, Marcel Hussing, Eric Eaton
openaire   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Research in place: the critical role of rural health research in Canada

Frontiers in Medicine
People in rural communities often experience different access to healthcare and services, which can lead to poorer health outcomes compared to their urban counterparts. This holds true across the international context, though our focus here is on Canada.
Stephanie Welton, Margo Wilson, Barbara Zelek, David Pontin, Grace Perez, Nelly D. Oelke, Nelly D. Oelke, Aaron Johnston, Aaron Johnston, Jill Konkin   +9 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The power of metaphor in medical education: fostering shared understanding in complex conversations

Frontiers in Medicine
Effective communication in medical education, particularly around complex or emotionally charged topics, remains a significant challenge. While numerous feedback frameworks exist, less attention has been paid to optimizing fundamental linguistic tools ...
Aaron Johnston, Aaron Johnston, Aaron Johnston, Sandra Andrawis, Grace Perez, Veronique Ram, Veronique Ram, Samuel Ogbeide, Samuel Ogbeide   +8 more
doaj   +1 more source

Weight exchange in distributed learning

2016 International Joint Conference on Neural Networks (IJCNN), 2016
Neural networks may allow different organisations to extract knowledge from the data they collect about a similar problem domain. Moreover learning algorithms usually benefit from being able to use more training instances. But the parties owning the data are not always keen on sharing it.
Julian Dorner, Samuel Favrichon, Arif Selçuk Ögrenci   +2 more
openaire   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source