Results 41 to 50 of about 352,189 (265)

Quasi-Distributed Dual-Parameter Optical Fiber Sensor Based on Cascaded Microfiber Fabry–Perot Interferometers

IEEE Photonics Journal, 2018
We propose and demonstrate a quasi-distributed fiber sensor based on cascaded microfiber Fabry–Perot interferometers (MFPIs) for simultaneous refractive index (RI) and temperature measurement.
Yang Xiang, Yiyang Luo, Yanpeng Li, Yue Li, Zhijun Yan, Deming Liu, Qinzhen Sun   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Characterizing and reducing equifinality by constraining a distributed catchment model with regional signatures, local observations, and process understanding [PDF]

Hydrology and Earth System Sciences, 2017
Distributed catchment models are widely used tools for predicting hydrologic behavior. While distributed models require many parameters to describe a system, they are expected to simulate behavior that is more consistent with observed processes ...
C. Kelleher, C. Kelleher, B. McGlynn, T. Wagener, T. Wagener   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Filtering for Linear Distributed Parameter Systems [PDF]

SIAM Journal on Control, 1970
Nonlinear filtering for linear parabolic distributed parameter systems with white noise, considering stochastic boundary value ...
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Three-Dimensional Fuzzy Modeling for Nonlinear Distributed Parameter Systems Using Simultaneous Perturbation Stochastic Approximation

Applied Sciences
Many systems in the manufacturing industry have spatial distribution characteristics, which correlate with both time and space. Such systems are known as distributed parameter systems (DPSs).
Xianxia Zhang, Tangchen Wang, Chong Cheng, Shaopu Wang   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Distributed Cooperative Control of Flexible Spacecraft Based on PDE-ODE Coupled Dynamics Model

Aerospace
With the increasing application of smart-material-based actuators for vibration suppression in flexible spacecraft, there is a growing need for advanced control strategies suited to distributed-parameter systems.
Kai Cao, Pan Sun, Zhitao Zhou, Fan Mo, Liguo Wang, Haiyang Li, Kaiheng Xiang, Shuang Li   +7 more
doaj   +1 more source