Results 51 to 60 of about 352,189 (265)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Exponential Stability of a Linear Distributed Parameter Bioprocess with Input Delay in Boundary Control

Journal of Function Spaces and Applications, 2013
We consider a linear distributed parameter bioprocess with boundary control input possessing a time delay. Using a simple boundary feedback law, we show that the closed-loop system generates a uniformly bounded -semigroup of linear operators under a ...
Fu Zheng, LingLing Fu, MingYan Teng
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Regional Stability and Stability Radius*

ESAIM: Proceedings and Surveys, 2015
In this work we consider the problem of stability, for distributed parameter systems, through the space variable. We give an extension of the stability radius, introduced by A. J. Pritchard and S. Townley [7, 10], to the regional case.
Bernoussi A., Bel Fekih A.
doaj   +1 more source

Ant System Initial Parameters Distribution

Elektronika ir Elektrotechnika, 2011
The paper presents some preliminary results on distributing initial parameter values among ants in Ant System. Two cases are studied, one with uniform distribution of heuristic information sensitivity values among ants and other with Gaussian distribution.
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

On Distributed Parameter System Identification with a Priori Information as Constraints

Engineering Transactions, 1984
The identification procedure presented in the paper makes it possible to determine the unloaded estimator of parameters of a system with distributed. parameters.
E. Rafajłowicz
doaj  

An integrodifferential approach to modeling, control, state estimation and optimization for heat transfer systems

International Journal of Applied Mathematics and Computer Science, 2016
In this paper, control-oriented modeling approaches are presented for distributed parameter systems. These systems, which are in the focus of this contribution, are assumed to be described by suitable partial differential equations.
Rauh Andreas, Senkel Luise, Aschemann Harald, Saurin Vasily V., Kostin Georgy V.   +4 more
doaj   +1 more source

Sensing linear viscoelastic constitutive parameters with a Timoshenko beam on a multi-layer foundation: Modeling and simulation

Sensing and Bio-Sensing Research, 2015
We present a sensor model comprised of a Timoshenko beam coupled with a linear viscoelastic substrate via a distributed system of compliant elements. The system of governing equations includes the evolution of the kinematic descriptors of the Timoshenko ...
Javad Fattahi, Davide Spinello
doaj   +1 more source