Results 71 to 80 of about 1,848,416 (344)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Exponential Stability of a Linear Distributed Parameter Bioprocess with Input Delay in Boundary Control

Journal of Function Spaces and Applications, 2013
We consider a linear distributed parameter bioprocess with boundary control input possessing a time delay. Using a simple boundary feedback law, we show that the closed-loop system generates a uniformly bounded -semigroup of linear operators under a ...
Fu Zheng, LingLing Fu, MingYan Teng
doaj   +1 more source

Ant System Initial Parameters Distribution

Elektronika ir Elektrotechnika, 2011
The paper presents some preliminary results on distributing initial parameter values among ants in Ant System. Two cases are studied, one with uniform distribution of heuristic information sensitivity values among ants and other with Gaussian distribution.
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Regional Stability and Stability Radius*

ESAIM: Proceedings and Surveys, 2015
In this work we consider the problem of stability, for distributed parameter systems, through the space variable. We give an extension of the stability radius, introduced by A. J. Pritchard and S. Townley [7, 10], to the regional case.
Bernoussi A., Bel Fekih A.
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

The BCS theory of q-deformed nucleon pairs - qBCS

, 2000
We construct a coherent state of q-deformed zero coupled nucleon pairs distributed in several single-particle orbits. Using a variational approach, the set of equations of qBCS theory, to be solved self consistently for occupation probabilities, gap ...
A. J. Macfarlane, D. Bonatsos, D. Bonatsos, Dennis Bonatsos, J. Bardeen, L. C. Biedenharn, M. Jimbo, M. Jimbo, N. K. Sharma, R. D. Lawson, S. L. Woronowicz, S. L. Woronowicz, S. Shelly Sharma, S. Shelly Sharma, S. Shelly Sharma, V. Pasquier, V. Pasquier   +16 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

On Distributed Parameter System Identification with a Priori Information as Constraints

Engineering Transactions, 1984
The identification procedure presented in the paper makes it possible to determine the unloaded estimator of parameters of a system with distributed. parameters.
E. Rafajłowicz
doaj  

An integrodifferential approach to modeling, control, state estimation and optimization for heat transfer systems

International Journal of Applied Mathematics and Computer Science, 2016
In this paper, control-oriented modeling approaches are presented for distributed parameter systems. These systems, which are in the focus of this contribution, are assumed to be described by suitable partial differential equations.
Rauh Andreas, Senkel Luise, Aschemann Harald, Saurin Vasily V., Kostin Georgy V.   +4 more
doaj   +1 more source