Results 81 to 90 of about 4,693,341 (291)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

A New Technology for Utilization of Biomass Hydrolysis Residual Humins for Acetic Acid Production

open access: yesBioResources, 2016
Humins are a major byproduct formed from acid-catalyzed biomass hydrolysis and are usually considered as a low-value material. In this work, humins were completely degraded by a two-step technology, involving alkaline-catalytic hydrothermal treatment ...
Shimin Kang   +6 more
doaj   +1 more source

PROBLEMS OF SYSTEMS WITH DISTRIBUTED GENERATION [PDF]

open access: yes, 2018
The problems of the development of modern production are related to the demand for electricity, which is ahead of the increase in generating capacity.
SUVORKIN, Olexsandr, TSYPLENKOV, Dmytro
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Distributed Functional Observers for LTI Systems

open access: yes, 2017
We study the problem of designing distributed functional observers for LTI systems. Specifically, we consider a setting consisting of a state vector that evolves over time according to a dynamical process.
Mitra, Aritra, Sundaram, Shreyas
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Power system effects and mitigation recommendations for DER cyberattacks

open access: yesIET Cyber-Physical Systems, 2019
Extensive deployment of interoperable distributed energy resources (DER) is increasing the power system cyber security attack surface. National and jurisdictional interconnection standards require DER to include a range of autonomous and commanded grid ...
Jay Johnson   +6 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The Clarens Web Service Framework for Distributed Scientific Analysis in Grid Projects [PDF]

open access: yes, 2005
Large scientific collaborations are moving towards service oriented architecutres for implementation and deployment of globally distributed systems. Clarens is a high performance, easy to deploy Web Service framework that supports the construction of ...
Ali, Arshad   +9 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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