Results 81 to 90 of about 1,327,655 (368)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An evaluation of load balancing algorithms for distributed systems [PDF]

open access: yes, 1991
Distributed systems are gradually being accepted as the dominant computing paradigm of the future. However, due to the diversity and multiplicity of resources, and the need for transparency to users, global resource management raises many questions.
Benmohammed-Mahieddine, Kouider
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Flexible Symmetrical Global-Snapshot Algorithmsfor Large-Scale Distributed Systems

open access: yes, 2014
Most existing global-snapshot algorithms in distributedsystems use control messages to coordinate the constructionof a global snapshot among all processes.
Jichiang Tsai
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Distributed systems and networks.

open access: yes, 2000
This book provides the student with comprehensive coverage of both networks and system architecture. It aims to introduce the most widely used networking protocols and distributed systems, covering recent developments in distributed processing and the ...
Buchanan, William J
core  

Simulation relations for systems with distributed interfaces

open access: yes, 2009
In this paper we define simulation relations for distributed systems. Taking as starting point our previous work on the distributed testing architecture, we introduce novel simulation relations that can be used to define, given a specification, what a ...
Manuel Núñez   +3 more
core   +1 more source

Distributed Simulation of Heterogeneous and Real-time Systems [PDF]

open access: yes, 2013
This work describes a framework for distributed simulation of cyber-physical systems (CPS). Modern CPS comprise large numbers of heterogeneous components, typically designed in very different tools and languages that are not or not easily composeable ...
Lasnier, Gilles   +9 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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