Results 161 to 170 of about 2,825,475 (318)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Another Characteristic Property of the Cauchy Distribution

The Annals of Mathematical Statistics, 1966
1. Main result. The purpose of this paper is to prove the theorem and corollary stated in this section. The corollary answers the question raised in Section 3 of [4] to which we also refer the reader for further motivation. THEOREM. Let X be a symmetric r.v., and Xi, i = 1, 2, , r.v.'s independently and identically distributed as X. The two conditions:
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Concentrations and Distribution Characteristics of Organochlorine Pesticides and Polychlorinated Biphenyls in Seawaters of the South Sea

Yankuang ceshi, 2014
In recent years, with the operation of coastal chemical production bases and booming maritime transportation of dangerous chemicals, there are threats to the marine environment.
Zhou tao, Han bin, Xu yayan, Liu xinmin, Zheng li, Wang xiaoru   +5 more
doaj  

Transient Characteristics Analysis of Distribution Network with Distributed PV

Proceedings of the 5th International Conference on Information Technologies and Electrical Engineering, 2022
Wenhui Mo, Jiran Zhu, Hengyi Zhou, Silin He, Haiguo Tang, Xiaoyuan Wang   +5 more
openaire   +1 more source

Portfolio Management under Asymmetric Dependence and Distribution [PDF]

Aim of our paper is to analyze the enhancement of portfolio management by using more sophisticated assumptions about distributions and dependencies of stock returns.
Peter Reichling, Stefan Hlawatsch
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Temporal-Spatial Characteristics and Ecological Risk Assessment of Heavy Metals, Sulfides and Organic Carbon in Sediment of Cage Aquaculture Area in Daqin Island

Haiyang Kaifa yu guanli
In order to understand the environmental status of the sediments in the cage culture area of Daqin Island and scientifically evaluate the ecological risk of the sediments in the area, the spatial and temporal distribution characteristics of heavy metals,
ZHAO Yuting, YU Xiaoxiao, HU Shunxin, SUN Wei, LIU Jiaqi, LIU Caili, WANG Liming, SUN Shan   +7 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Growth, Income Distribution, and Poverty: A Review [PDF]

Pro-poor growth, Income distribution, Poverty ...
Bigsten, Arne, Levin, Jorgen
core