Results 91 to 100 of about 427,721 (311)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Fitting Methods for Probability Distribution Functions in Turbulent Star-forming Clouds

The Astrophysical Journal
We use a suite of 3D simulations of star-forming molecular clouds, with and without stellar feedback and magnetic fields, to investigate the effectiveness of different fitting methods for volume and column density probability distribution functions (PDFs)
Avery Kiihne, Sabrina M. Appel, Blakesley Burkhart, Vadim A. Semenov, Christoph Federrath   +4 more
doaj   +1 more source

S4. Fitting model candidates to high-fidelity D^3j datasets from Anchoring the mean generation time in the SEIR to mitigate biases in ℜ₀ estimates due to uncertainty in the distribution of the epidemiological delays

, 2023
Jair Andrade, Jim Duggan
openalex   +1 more source

Automated Phase-Type Distribution Fitting via Expectation-Maximization [PDF]

, 2023
Marco Mialaret, Paulo A. Pereira, Antônio Sá Barreto, Thiago Pinheiro, Paulo Maciel   +4 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Fitting the spectral energy distributions of galaxies with CIGALE : Code Investigating GALaxy Emission [PDF]

, 2012
É. Giovannoli, V. Buat
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Oceanic Mesoscale Eddy Fitting Using Legendre Polynomial Surface Fitting Model Based on Along-Track Sea Level Anomaly Data

Remote Sensing
Exploring the spatial distribution of sea surface height involves two primary methodologies: utilizing gridded reanalysis data post-secondary processing or conducting direct fitting along-track data.
Chunzheng Kong, Yibo Zhang, Jie Shi, Xianqing Lv   +3 more
doaj   +1 more source