Results 71 to 80 of about 5,184,155 (262)

A fast method for fitting integrated species distribution models

Methods in Ecology and Evolution
Integrated distribution models (IDMs) predict where species might occur using data from multiple sources, a technique thought to be especially useful when data from any individual source are scarce. Recent advances allow us to fit such models with latent
Elliot Dovers, Gordana C. Popovic, David I. Warton   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Derivation of a novel probability distribution for fitting different data

Scientific African
Probability distributions play a pivotal role in statistical modeling by providing essential frameworks for representing real-world phenomena. However, the inherent variability and complexity of modern datasets often challenge the applicability of ...
Ahmed M. Gemeay, Hanene Hamdani, Mustafa Ibrahim Ahmed Araibi, Sule Omeiza Bashiru, Elbatal I., Ehab M. Almetwally, Laxmi Prasad Sapkota   +6 more
doaj   +1 more source

Distribution Fitting.

, 2012
Distribution fitting for the brain cancer dataset for RMA (top) and DChip (bottom) normalized data. The three best-fit curves are superimposed on the histogram, and the normal distribution curve is included for comparison. The specific parameters for the
Robert J. Weil (123848), Nicholas F. Marko (123844)   +1 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

PREDICTION OF AIRCRAFT NORMAL OVERLOAD EXTREME VALUE BASED ON PEARSON-Ⅲ DISTRIBUTION

Jixie qiangdu, 2018
Based on Pearson-Ⅲ distribution（ P-Ⅲ） representing much capacity for fitting extreme value data,research on Nzextreme values were carried on. Calculation method on the deviation coefficients Φp of skew coefficients Cswas deduced and established,which ...
LEI XiaoBo, WEN Min, LEI DiYuan, ZHANG XiaMei   +3 more
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source