Results 91 to 100 of about 478,084 (316)
Distributions of Beneficial Fitness Effects in RNA [PDF]
Genetics, 2005 Abstract Beneficial mutations are the driving force of evolution by natural selection. Yet, relatively little is known about the distribution of the fitness effects of beneficial mutations in populations. Recent work of Gillespie and Orr suggested some of the first generalizations for the distributions of beneficial fitness effects and ...
Matthew C, Cowperthwaite +2 more
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Enlightening the Relationship Between Distribution and Regression Fitting
, 2017 Part 3: Big Data Analysis and Machine LearningInternational audienceStatistical distribution fitting and regression fitting are both classic methods to model data.
Guo, Ping +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Fitting the empirical distribution of intertrade durations
, 2008 Based on the analysis of a tick-by-tick data set used in the previous work by one of the authors (DJIA stocks traded at NYSE in October 1999), in this paper, we reject the hypothesis that tails of the empirical intertrade distribution are described by a
Enrico Scalas (4464904) +3 more
core +1 more source
Knowledge Distillation Based on Fitting Ground-Truth Distribution of Images
Applied SciencesKnowledge distillation based on the features from the penultimate layer allows the student (lightweight model) to efficiently mimic the internal feature outputs of the teacher (high-capacity model).
Jianze Li +3 more
doaj +1 more source
Revista Colombiana de Estadística, 2015 In this article we study a subfamily of the slashed-Weibull family. This subfamily can be seen as an extension of the Rayleigh distribution with more flexibility in terms of the kurtosis of distribution.
YURI A. IRIARTE +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Extract Signals by Fitting $χ^2$ Distribution of the Kinematic Fit
, 2006 3 pages, 2 ...
Rong-Gang, Ping +7 more
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source