Results 191 to 200 of about 3,055,792 (311)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High-quality ultra-fast total scattering and pair distribution function data using an X-ray free-electron laser. [PDF]

IUCrJ
Sapnik AF, Chater PA, Keeble DS, Evans JSO, Bertolotti F, Guagliardi A, Støckler LJ, Harbourne EA, Borup AB, Silberg RS, Descamps A, Prescher C, Klee BD, Phelipeau A, Ullah I, Medina KG, Bird TA, Kaznelson V, Lynn W, Goodwin AL, Iversen BB, Crepisson C, Bozin ES, Jensen KMØ, McBride EE, Neder RB, Robinson I, Wark JS, Andrzejewski M, Boesenberg U, Brambrink E, Camarda C, Cerantola V, Goede S, Höppner H, Humphries OS, Konopkova Z, Kujala N, Michelat T, Nakatsutsumi M, Pelka A, Preston TR, Randolph L, Roeper M, Schmidt A, Strohm C, Tang M, Talkovski P, Zastrau U, Appel K, Keen DA.   +50 more
europepmc   +1 more source

Probability Distribution Function of Near-Wall Turbulent Velocity Fluctuations

, 2005
By large eddy simulation (LES), turbulent databases of channel flows at different Reynolds numbers were established. Then, the probability distribution functions of the streamwise and wall-normal velocity fluctuations were obtained and compared with the ...
张强, Zhou, JF (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China., 李家春, 周济福   +3 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

White Matter Bundle Reconstruction From Single-Shell Diffusion Magnetic Resonance Imaging: Test-Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods. [PDF]

Hum Brain Mapp
Rauland A, Meisler SL, Alexander-Bloch AF, Bagautdinova J, Baller EB, Gur RE, Gur RC, Luo AC, Moore TM, Popovych OV, Reetz K, Roalf DR, Shinohara RT, Sotardi S, Sydnor VJ, Vossough A, Eickhoff SB, Cieslak M, Satterthwaite TD.   +18 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Sub-second pair distribution function using a broad bandwidth monochromator. [PDF]

J Appl Crystallogr, 2023
Magnard NPL, Sørensen DR, Kantor I, Jensen KMØ, Jørgensen MRV.   +4 more
europepmc   +1 more source

On distribution functions with a limiting stable distribution function [PDF]

Arkiv för Matematik, 1953
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Solving disorder in (3D) real space: a comparative study of the three-dimensional difference pair distribution function and atomic resolution holography reconstructions. [PDF]

J Appl Crystallogr
Stellhorn JR, Minelli A, Meekel EG, Schmidt EM.   +3 more
europepmc   +1 more source