Results 81 to 90 of about 12,478,031 (344)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A real-time topology identification method of distribution networks based on CNN-LSTM-Attention

Zhejiang dianli
Accurate identification of the topology in a distribution network is crucial for its operation and control. Addressing the dynamic changes in the actual topology of distribution networks， an intelligent deep learning model capable of recognizing ...
LING Jiakai, ZHANG Yizhou, HU Jinfeng, QIN Jun, DAI Jian, FEI Youdie, ZHU Zhen   +6 more
doaj   +1 more source

Distributed Transactive Energy Trading Framework in Distribution Networks

IEEE Transactions on Power Systems, 2018
In this paper, we propose a novel transactive energy trading (TET) framework to deal with the economic issues in energy trading and the technical issues in distribution system operation in a holistic manner.
Jiayong Li, Chaorui Zhang, Zhao Xu, Jianhui Wang, Jian Zhao, Y. Zhang   +5 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

New modelling of photovoltaic power integration system and its control strategy for medium-voltage DC distribution network

The Journal of Engineering, 2019
Here, a novel photovoltaic power integration system based on LLC resonant converters is proposed for medium-voltage DC distribution network, which exhibits a feasible and efficient solution for large-scale solar energy integrating into DC grids.
Jiaxi Chen, Daozhuo Jiang, Rui Yin, Yiqiao Liang   +3 more
doaj   +1 more source

Development of a Decision-Making Algorithm for the Optimum Size and Placement of Distributed Generation Units in Distribution Networks

, 2017
The paper presents a decision-making algorithm that has been developed for the optimum size and placement of distributed generation (DG) units in distribution networks.
V. Vita
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Three‐phase four‐wire power flow solution for multi‐grounded distribution networks with non‐bolted grounding

IET Generation, Transmission & Distribution
This study proposes a direct ZBUS three‐phase four‐wire power flow method to accurately analyse the neutral line and multiple grounding characteristics.
Nien‐Che Yang, Song‐Ting Zeng
doaj   +1 more source