Results 101 to 110 of about 15,786,892 (337)
Load distribution in small world networks
, 2005 In this paper we introduce a new model of data packet transport, based on a stochastic approach with the aim of characterizing the load distribution on complex networks.
di Bernardo, M. +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A comprehensive statistical study of metabolic and protein-protein interaction network properties
, 2018 Understanding the mathematical properties of graphs underling biological systems could give hints on the evolutionary mechanisms behind these structures.
Gamermann, D., Jaime, R., Triana, J.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Scale-free networks are not robust under neutral evolution
, 2001 Recently it has been shown that a large variety of different networks have power-law (scale-free) distributions of connectivities. We investigate the robustness of such a distribution in discrete threshold networks under neutral evolution.
Bollobás B. +7 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A real-time topology identification method of distribution networks based on CNN-LSTM-Attention
Zhejiang dianliAccurate identification of the topology in a distribution network is crucial for its operation and control. Addressing the dynamic changes in the actual topology of distribution networks， an intelligent deep learning model capable of recognizing ...
LING Jiakai +6 more
doaj +1 more source
Quantification and Comparison of Degree Distributions in Complex Networks
, 2013 The degree distribution is an important characteristic of complex networks. In many applications, quantification of degree distribution in the form of a fixed-length feature vector is a necessary step.
Aliakbary, Sadegh +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Journal of Engineering, 2019 Here, a novel photovoltaic power integration system based on LLC resonant converters is proposed for medium-voltage DC distribution network, which exhibits a feasible and efficient solution for large-scale solar energy integrating into DC grids.
Jiaxi Chen +3 more
doaj +1 more source