Results 111 to 120 of about 7,946,745 (307)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Study on the start-up and fault-restart strategies and reactive power analysis of DC distribution systems

open access: yesThe Journal of Engineering, 2019
The DC distribution network is becoming the basic supporting component of the urban distribution network. A variety of power supplies, loads, and energy storage devices can be directly integrated into a DC distribution network, which can improve the ...
Rui Li   +5 more
doaj   +1 more source

Distributed Paging for General Networks

open access: yesJournal of Algorithms, 1998
Summary: Distributed paging deals with the dynamic allocation of copies of files in a distributed network as to minimize the total communication cost over a sequence of read and write requests. Most previous work deals with the file allocation problem, where infinite nodal memory capacity is assumed. In contrast the distributed paging problem makes the
Baruch Awerbuch, Yair Bartal, Amos Fiat
openaire   +4 more sources

The Spatial Structure of Production/Distribution Networks and Its Implication for Technology Transfers and Spillovers [PDF]

open access: yes
This paper argues that a variety of firm specificity supported by sophisticated inter-firm relationships is essential for understanding the mechanics and spatial structure of international production/distribution networks in East Asia. By mapping the two-
Fukunari KIMURA
core  

On-line monitoring for operational control of water distribution networks [PDF]

open access: yes, 1992
This work concerns the concept of on-line monitoring and control for water distribution networks. The problem is simple to state. It is to produce a robust scheme that can continuously provide reliable information about the state of a water network in ...
Powell, R.S., Powell, R
core  

Multi-objective Modeling and Optimization for DG-Owner and Distribution Network Operator in Smart Distribution Networks

open access: yes, 2018
The political initiatives of the last decades on energy saving and the power generation decarbonization are forcing distributors to implement actions that increase the hosting capacity for new renewable generation on their systems without worsening the ...
Celli G   +4 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Voltage balance improvement in urban low voltage distribution networks [PDF]

open access: yes, 2015
This project is a step forward in developing effective methods to mitigate voltage unbalance in urban residential networks. The method is proposed to reduce energy losses and improve quality of service in strongly unbalanced low-voltage networks.
Pezeshki, Houman
core  

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