Results 121 to 130 of about 7,946,745 (307)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A CO-SIMULATION TOOL FOR ACTIVE DISTRIBUTION NETWORKS

, 2014
A co-simulation tool for active distribution networks is presented that links Open Distribution System Simulator with ns-2 Network Simulator software for conjunct simulations of electrical and communication systems.
CORTI S, PILO, FABRIZIO GIULIO LUCA, GHIANI, EMILIO, CELLI, GIANNI, GARAU M   +4 more
core  

Greening Video Distribution Networks

, 2018
The chapter focuses in particular on energy-efficiency issues in the context of video distribution networks (VDNs), where additional paradigms, as content delivery and caching operations, play a relevant role.
Raffaele Bolla, Franco Davoli, Etienne Victor Depasquale, Roberto Bruschi, Popescu, Adrian, SpringerLink (Online service), Popescu, Adrian,, Popescu, Adrian.editor.edthttp://id.loc.gov/vocabulary/relators/edt   +7 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Adaptive convergence enhancement strategies for Newton–Raphson power flow solutions in distribution networks

IET Generation, Transmission & Distribution
This study introduces a series of strategies to enhance convergence in the Newton–Raphson power flow method for unbalanced distribution networks. The proposed approach incorporates graph theory, Kron reduction, and current injection techniques.
Nien‐Che Yang, Chih‐Hsiung Tseng
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Peer‐to‐peer electricity trading via a bi‐level optimization approach for renewable energy‐driven microgrids connected to the distribution grid

IET Generation, Transmission & Distribution
This study employs a sophisticated bi‐level optimization methodology to model the most efficient operation of microgrids (MGs) within the operational framework of distribution companies (DCs).
Hamid Helmi, Taher Abedinzadeh, Jamal Beiza, Sima Shahmohammadi, Ali Daghigh   +4 more
doaj   +1 more source

Operation of distributed energy resources in smart distribution networks /

Operation of Distributed Energy Resources in Smart Distribution Networks defines the barriers and challenges of smart distribution networks, ultimately proposing optimal solutions for addressing them.
Nojavan, Sayyad,editor., Zare, Kazem,editor.   +1 more
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source