Results 151 to 160 of about 173,569,965 (255)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Amazon Prime distribution deal

, 2019
Distribution deal published by Amazon Prime for the Love Works ...
Jessop, Kate
core  

Inverse Code: A Low-density MDS Horizontal Array Code Tolerating Triple Faults

工程科学与技术, 2017
:Array codes are widely used to improve the fault tolerance ability of redundant arrays inindependent disks(RAID) storage system.With the in-depth understanding of RAID storage system,the update efficiency of array codes has gradually become an important
doaj  

Persistence and recovery of reproductive underperformance across successive parities in commercial sows. [PDF]

Front Vet Sci
Lili N, Mpetile Z, Mndela M, Akinmoladun OF.   +3 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Fishing with two lines: a hybrid approach to spatial transcriptomics discovery. [PDF]

Life Sci Alliance
Williams-Katek AL, Mallapragada S, Mee ED, Fischer BK, Vannan A, Eldredge LC, Deutsch GH, Kropski JA, Sucre JM, Banovich NE.   +9 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV-Important Lessons Learned. [PDF]

J Med Primatol
Tenbusch M, Koopman G, Mooij P, Roshani B, Irrgang P, Lapuente D, Kondova I, Bogers WM, Remarque EJ, Vestweber R, Merida Ruiz SA, Krüger N, Meyer S, Gefeller O, Stahl-Hennig C, Überla K.   +15 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Amplification of computational power by the multiplication of bacteria exploring microfluidic networks encoding mathematical problems. [PDF]

Microsyst Nanoeng
Sudalaiyadum Perumal A, van Delft FCMJM, Ippoliti G, Kašpar O, Tokárová V, Nayak M, Cho M, Li J, van Langen-Suurling A, de Boer C, Dirne F, Nicolau DV, Nicolau DV.   +12 more
europepmc   +1 more source