Results 171 to 180 of about 76,351 (297)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Antibody-mediated diversification of primary and secondary humoral immune responses. [PDF]

J Exp Med
Schaefer-Babajew D, Binet L, Silva Santos GS, Ruprecht C, Deimel LP, ElTanbouly MA, Gharrassi D, Lima Dos Reis G, Uhe C, Yao KH, Hernandez B, Agrawal P, Gazumyan A, Stamatatos L, Hartweger H, Nussenzweig MC.   +15 more
europepmc   +1 more source

A Note on the Distribution of Differences between Consecutive Prime Numbers

, 2004
Working paper.The results reported in this note refer to the distribution of zn = pn - pn-1 for the first three million prime numbers (p). The analyses of the note are almost purely statistical. The difference between consecutive prime numbers is treated
Taylor, Lester D.
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines. [PDF]

Nat Immunol
Jena KK, Qu P, Baracco L, Saghaei S, Keerti, Allahyari Z, Boehmer D, Mitchell M, Dillen CA, Li HY, Liu E, Poli V, Dufies O, Hoytema van Konijnenburg DP, Spreafico R, Bi C, Hall R, Kruppa MD, Ma Z, Gravitte A, Lowman DW, Ensley HE, Marty P, Boyer L, Collomp R, Williams DL, Ma VP, Lee PY, Nigrovic PA, Karp JM, Elledge SJ, Wesemann DR, Wu Y, Frieman M, Zanoni I.   +34 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Codon bias shapes bacterial small RNA binding sites within protein-coding sequences. [PDF]

RNA
Fisher S, Margalit H.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Tuning Rice Gene Expression via In Situ Promoter Truncations Using a Prime Editing Library. [PDF]

Plant Biotechnol J
Li Y, Xu B, Gao X, Wang Y, Liu X, Xu R, Li J, Wei P, Qin R.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source