Results 81 to 90 of about 4,328,597 (294)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Embedding Consumer Taste for Location into a Structural Model of Equilibrium [PDF]

open access: yes
Given that brands (products) are location specific in terms of coverage of retail stores, we allow consumers to have preferences over location and products to carry distribution costs, alongside preferences and costs over other observable and ...
Franco Mariuzzo, Patrick Paul Walsh
core   +3 more sources

The distribution of evaporitic weathering products on Antarctic meteorites [PDF]

open access: yes
White evaporite deposits of terrestrial origin occur on some 5 percent of Antarctic meteorites. The few previous studies, and new mineralogical analyses, indicate that the deposits are predominately carbonates and/or sulfates of magnesium.
Velbel, Michael A.
core   +1 more source

ON MIKUSINSKI TYPE PRODUCTS OF DISTRIBUTIONS

open access: yesDemonstratio Mathematica, 2000
Summary: The well known result of Jan Mikisiński on distributed products: \(x^{-1},x^{-1}- \pi^2\delta^2(x)= x^{-2}\), \(x\in\mathbb{R}\), is generalized here for the distributions \(x^{-p}\) and \(\delta^{(p-1)}(x)\) for arbitrary natural \(p\). To this aim we follow the method of Mikusiński of employing a `Fourier-product' formula, which is done in ...
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Product of Boundary Distributions

open access: yes, 2001
1) We identify new parameter branches for the ultra-local boundary Poisson bracket in d spatial dimension with a (d-1)-dimensional spatial boundary. There exist 2^{r(r-1)/2} r-dimensional parameter branches for each d-box, r-row Young tableau. The already known branch (hep-th/9912017) corresponds to a vertical 1-column, d-box Young tableau.
openaire   +2 more sources

Distributive Lattices and Products of Capacities

open access: yesJournal of Mathematical Analysis and Applications, 1998
It is shown that any normalized capacity on a finite set can be considered as the geometrical realization of a distributive lattice. Then the product of capacities is defined.
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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