Results 131 to 140 of about 910,941 (356)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Distribution of clinical risk factors for fracture in a Brussels cohort of postmenopausal women: The FRISBEE study and comparison with other major cohort studies [PDF]

, 2017
Sylvie Cappelle, Isolde Ramon, C. Dekelver, Serge Rozenberg, Felicia Baleanu, Rafik Karmali, Michel Rubinstein, Marianne Tondeur, Michel Moreau, Marianne Paesmans, P. Bergmann, Jean‐Jacques Body   +11 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Influence of coastal groundwater salinization on the distribution and risks of heavy metals.

Science of the Total Environment, 2019
X. Wen, Jian Lu, Jun Wu, Yichen Lin, Yongming Luo   +4 more
semanticscholar   +1 more source

Environmental risks of microplastics: A Review of their distribution and effects on aquatic ecosystems [PDF]

Yan Zuo, Longfei Ma, Z.-X. Liu, Sheng Li, Zichao Zhang, Jia Yu   +5 more
openalex   +1 more source

RISK DISTRIBUTION AT THE STAGE OF CONCLUSION OF THE CONTRACT ON THE EXAMPLE OF A NON-RESIDENTIAL PREMISES LEASE AGREEMENT [PDF]

, 2020
Lyudmila A. Spektor, R.D. Zhmurko
openalex   +1 more source

Spatial distribution of nutrients and risk of eutrophication of Lake Tengrela in the municipality of Banfora in Burkina Faso. [PDF]

, 2023
Tiraogo Prince Florian Bouda, Yélézouomin Somé   +1 more
openalex   +1 more source

Risk assessment of distribution network operation with scale distributed photovoltaics

Journal of Physics: Conference Series
Abstract In the context of large-scale photovoltaic integration into the distribution network, it is of great significance to comprehensively consider the uncertainty of photovoltaic output and load and scientifically and effectively evaluate the operational risks of the distribution network, in order to ensure the reliable and economic ...
Xiaofang Guo, Guixi Miao, Xin Wang, Liang Yuan, Wen Li, Entong Wu, Xierzhati Yibulayimu   +6 more
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source