Results 111 to 120 of about 642,937 (309)

The Business Going Concern: Financial Return and Social Expectations

open access: yes, 2020
The present work aims to analyze the corporate social responsibility from a new perspective, observing the link between a progression of business and the distribution of risks between different expectations.
Faccia A   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Municipal distribution of ovarian cancer mortality in Spain

open access: yesBMC Cancer, 2008
Background Spain was the country that registered the greatest increases in ovarian cancer mortality in Europe. This study describes the municipal distribution of ovarian cancer mortality in Spain using spatial models for small-area analysis.
Vidal Enrique   +9 more
doaj   +1 more source

Distributions of Risk Functions for the Pareto Model

open access: yesOpen Journal of Statistics
In statistical decision theory, the risk function quantifies the average performance of a decision over the sample space. The risk function, which depends on the parameter of the model, is often summarized by the Bayes risk, that is its expected value with respect to a design prior distribution assigned to the parameter.
De Santis, Fulvio   +2 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Equity Release Mortgages

open access: yes, 2017
This chapter is dedicated to equity reversemortgages,which are greatly affected by negative equity so implicitly by real-estate risk. For reverse mortgages negative equity is not a trigger for defaults as with standard mortgages.
Radu S. Tunaru
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Risk Modeling of a Gas Industry Distribution Process using Bayesian Networks [PDF]

open access: yesMuhandisī-i bihdāsht-i ḥirfah/ī
Background and Objective: Safety issues of natural gas pipelines have become an important issue in recent years. In this regard, risk analysis of gas pipelines has received attention, and approaches related to the identification and determination of ...
Kambiz MohammadPour   +1 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Predicting Conservation Status of Testudoformes under Climate Change Using Habitat Models

open access: yesAnimals
Climate change promotes variations in distribution ranges, potentially leading to biodiversity loss and increased extinction risks for species. It is crucial to investigate these variations under future climate change scenarios for effective biodiversity
Wenbo Liao   +5 more
doaj   +1 more source

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