Results 141 to 150 of about 1,853,872 (317)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Grain size, size-distribution and dislocation structure from diffraction peak profile analysis

, 2002
Diffraction peak profile analysis (or Line Profile Analysis, LPA) has recently been developed to such an extent that it can be applied as a powerful method for the characterization of microstructures of crystalline materials in terms of crystallite ...
Gubicza, Jenő, Ungár, Tamás
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Modeling of recurrent noise pattern in low voltage distribution lines

, 2009
Power Line Communication (PLC), Power Line Telecommunication (PLT), o Broadband over Power Line (BPL) es una tecnología que plantea el uso de las líneas de distribución eléctrica de baja y media tensión para la prestación de servicios de ...
Moreno Coy, Octavio Andrés
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Micropaleontological investigations in the modern Mahakam delta, East Kalimantan (Indonesia)

Carnets de Géologie, 2003
The Mahakam delta is a mixed, fluvial and wave dominated delta located in the eastern part of the island of Borneo (the East Kalimantan province of Indonesia).
Lambert Bernard
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

An unconventional distribution pattern of retinal ganglion cells in the giant panda (Ailuropoda melanoleuca)

, 2017
PURPOSE:: Characterize the vertical distribution pattern of retinal ganglion cells in the giant panda. Methods: Four eyeballs were immediately collected from deceased adult pandas. Routine immunohistochemical staining techniques were applied to label
D. Li, R. Wei, L. Deng, C. Wang, W. Wang, M. Pu, Y. Nan, J. Gao, Y. Zhou, C. Zhang   +9 more
core  

Bug distribution and statistical pattern classification

rule space model, cognitive error diagnosis, task analysis, error analysis, bug distribution, Bayes' decision rules, pattern classification, item response theory, stochastic model,
Kikumi Tatsuoka, Maurice Tatsuoka
core   +1 more source