Results 211 to 220 of about 3,308,530 (269)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Fungal contamination of the water distribution system of a tertiary hospital water supply system in a resource-limited setting. [PDF]

Ther Adv Infect Dis
Olawale KS, Oladele RO, Peters RF, Ekeng BE, Ogunsola FT.   +4 more
europepmc   +1 more source

Implementation, delivery, and utilization of iron fortified rice supplied through public distribution system across different states in India: An exploratory mixed-method study. [PDF]

PLOS Glob Public Health
Nandeep ER, Mahajan H, Mummadi MK, Sairam C, K V, Kadiyam J, Meshram I, Pagidoju S, Reddy VR, Panda H, Pullakandham R, Geddam JJB, Gavaravarapu SM, R H, Reddy N S.   +14 more
europepmc   +1 more source

End-to-End Encrypted Message Distribution System for the Internet of Things Based on Conditional Proxy Re-Encryption. [PDF]

Sensors (Basel)
Lin S, Cui L, Ke N.
europepmc   +1 more source

Integrating Distributed Algorithms into Distributed Systems [PDF]

Fundamenta Informaticae, 1999
A distributed algorithm is often used as a part of a larger distributed system. Usually, the properties of an algorithm are proven for the algorithm in isolation. Then, it is not obvious how the algorithm behaves when integrated into a larger system. In this paper, we present a simple technique which allows to derive properties of an algorithm which is
Ekkart Kindler, Sibylle Peuker
openaire   +2 more sources

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Distributed Systems

Computer, 1985
Growth of distributed systems has attained unstoppable momentum. If we better understood how to think about, analyze, and design distributed systems, we could direct their implementation with more confidence.
openaire   +1 more source

On a System of Discrete Distributions

Biometrika, 1967
Using the difference equation analogous to Pearson's differential equation, a system of discreate distributions is developed. This is found to contain many of the distributions in common usage. The choice of distribution usually depends on only the first three moments. Some examples are given.
openaire   +3 more sources