Results 211 to 220 of about 3,326,680 (269)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Fungal contamination of the water distribution system of a tertiary hospital water supply system in a resource-limited setting. [PDF]

Ther Adv Infect Dis
Olawale KS, Oladele RO, Peters RF, Ekeng BE, Ogunsola FT.   +4 more
europepmc   +1 more source

End-to-End Encrypted Message Distribution System for the Internet of Things Based on Conditional Proxy Re-Encryption. [PDF]

Sensors (Basel)
Lin S, Cui L, Ke N.
europepmc   +1 more source

Implementation, delivery, and utilization of iron fortified rice supplied through public distribution system across different states in India: An exploratory mixed-method study. [PDF]

PLOS Glob Public Health
Nandeep ER, Mahajan H, Mummadi MK, Sairam C, K V, Kadiyam J, Meshram I, Pagidoju S, Reddy VR, Panda H, Pullakandham R, Geddam JJB, Gavaravarapu SM, R H, Reddy N S.   +14 more
europepmc   +1 more source

Integrating Distributed Algorithms into Distributed Systems [PDF]

Fundamenta Informaticae, 1999
A distributed algorithm is often used as a part of a larger distributed system. Usually, the properties of an algorithm are proven for the algorithm in isolation. Then, it is not obvious how the algorithm behaves when integrated into a larger system. In this paper, we present a simple technique which allows to derive properties of an algorithm which is
Ekkart Kindler, Sibylle Peuker
openaire   +2 more sources

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Dissipative distributed systems

Proceedings of the 39th IEEE Conference on Decision and Control (Cat. No.00CH37187), 2002
Deals with systems described by constant coefficient linear partial differential equations. We define dissipativity with respect to a quadratic differential form, i.e., a quadratic functional in the system variables and their partial derivatives. The main result states the equivalence of dissipativity and the existence of a storage function or of a ...
Harish K. Pillai, Jan C. Willems
openaire   +1 more source

Distributed Systems

Computer, 1985
Growth of distributed systems has attained unstoppable momentum. If we better understood how to think about, analyze, and design distributed systems, we could direct their implementation with more confidence.
openaire   +1 more source