Results 141 to 150 of about 41,764,182 (312)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
, 2012 Copper sulphate dosed as a nitrifier inhibitor in water distribution systems has encountered dramatic loss due to iron pipe corrosion. Chosen as the representative of iron corrosion products, ferric hydroxide flocs at low concentration (
Sathasivan, Arumugam (R17016) +2 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Techno-economic analysis of distribution system at various load models using MEWOA algorithm
Scientific ReportsIn response to the market’s increasing need for electricity and the escalating technical and environmental challenges, the Power System (PS) sector has strongly emphasised the escalating technical and ecological challenges, and the PS sector has placed a
Rinchen Zangmo +5 more
doaj +1 more source
Understanding environmental trade-offs of carbon capture, utilization and storage [PDF]
, 2017 Climate change caused by the rise of anthropogenic greenhouse gas (GHG) emissions is one of the challenges mankind has to face in the coming years. The deployment of carbon capture and storage (CCS) and potentially CO2 utilization (CCU) technologies are ...
Energy System Analysis +2 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Toward a Post-Sraffian Theory of Income Distribution
, 1994 After recalling the Sraffian critiques to marginalist distribution theory, and hence the need for a different approach, the paper illustrates the classical conceptualization of social classes and its flexibility for the application to the modern world ...
Roncaglia, A.
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