Results 121 to 130 of about 2,032 (302)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Decomposition Methods For Solving Distributionally Robust Two-Stage Stochastic Integer Programs

open access: yes, 2018
We introduce and study a two-stage distributionally robust mixed binary problem (TSDR-MBP) where the random parameters follow the worst-case distribution belonging to an uncertainty set of probability distributions.
Mehrotra, Sanjay
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Distributionally Robust Optimization with SOS Polynomial Density Functions and Moment Conditions

open access: yes, 2018
Numerous decision problems are solved using the tools of distributionally robust optimization. In this framework, the distribution of the problem's random parameter is assumed to be known only partially in the form of, for example, the values of its ...
Postek, Krzysztof
core  

Carbon-aware mobile energy storage system scheduling in active power distribution systems under PV and traffic uncertainties

open access: yesEnergy Reports
Carbon emission flow (CEF) is a promising approach for assessing both generation-and consumption-side carbon footprints in the power system sector. In this study, we propose a carbon-aware mobile energy storage system (MESS) scheduling framework that ...
Panggah Prabawa, Dae-Hyun Choi
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Splitting Algorithms for Distributionally Robust Optimization

open access: yes
25 ...
Briceño-Arias, Luis   +2 more
openaire   +3 more sources

Distributionally Robust Bayesian Optimization via Sinkhorn-Based Wasserstein Barycenter

open access: yesMachine Learning and Knowledge Extraction
This paper introduces a novel framework for Distributionally Robust Bayesian Optimization (DRBO) with continuous context that integrates optimal transport theory and entropic regularization.
Iman Seyedi   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

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