Results 51 to 60 of about 337,938 (272)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Feynman-Hellmann Theorem and Signal Identification from Sample Covariance Matrices

Physical Review X, 2014
A common method for extracting true correlations from large data sets is to look for variables with unusually large coefficients on those principal components with the biggest eigenvalues.
Lucy J. Colwell, Yu Qin, Miriam Huntley, Alexander Manta, Michael P. Brenner   +4 more
doaj   +1 more source

Bounds on the spectral shift function and the density of states

, 2004
We study spectra of Schr\"odinger operators on $\RR^d$. First we consider a pair of operators which differ by a compactly supported potential, as well as the corresponding semigroups.
Hundertmark, Dirk, Killip, Rowan, Nakamura, Shu, Stollmann, Peter, Veselic', Ivan   +4 more
core   +6 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Using National Survey Respondents as Consumers in an Agent-Based Model of Plug-In Hybrid Vehicle Adoption

IEEE Access, 2015
Plug-in hybrid electric vehicles (PHEVs) offer the potential to significantly reduce greenhouse gas emissions, if vehicle consumers are willing to adopt this new technology. Consequently, there is much interest in exploring PHEV market penetration models.
Margaret J. Eppstein, Donna M. Rizzo, Brian H. Y. Lee, Joseph S. Krupa, Narine Manukyan   +4 more
doaj   +1 more source

Approximate Distribution of Hitting Probabilities for a Regular Surface with Compact Support in 2D [PDF]

, 2002
Generalizing the well-known relations on characteristic functions on a plane to the case of a one-dimensional regular surface (curve) with compact support, we establish implicit equations for these functions. Introducing an approximation, we solve the combinatorial problems and reduce these equations to a set of linear equations for a finite number of ...
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Summertime surface PM₁ aerosol composition and size by source region at the Lampedusa island in the central Mediterranean Sea [PDF]

Atmospheric Chemistry and Physics, 2019
Measurements of aerosol composition and size distributions were taken during the summer of 2013 at the remote island of Lampedusa in the southern central Mediterranean Sea.
M. D. Mallet, M. D. Mallet, M. D. Mallet, B. D'Anna, B. D'Anna, A. Même, A. Même, M. C. Bove, M. C. Bove, F. Cassola, F. Cassola, G. Pace, K. Desboeufs, C. Di Biagio, J.-F. Doussin, M. Maille, D. Massabò, J. Sciare, P. Zapf, A. G. di Sarra, P. Formenti   +20 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source