Results 91 to 100 of about 796,821 (312)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

District heating networks in the framework of spatial planning [PDF]

, 2014
The way to a more sustainable energy future is running over a transition process that drives change in our views and actions on renewables, emissions and efficiencies.
Van Eetvelde, Greet, Vansteenbrugge, Joke   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Carbon Free Boston: Energy Technical Report [PDF]

, 2019
Part of a series of reports that includes: Carbon Free Boston: Summary Report; Carbon Free Boston: Social Equity Report; Carbon Free Boston: Technical Summary; Carbon Free Boston: Buildings Technical Report; Carbon Free Boston: Transportation ...
Cleveland, Cutler J., Fox-Penner, Peter, Pollack, Adam, Walsh, Michael J., Zheng, Kevin   +4 more
core  

Low Temperature District Heating for Future Energy Systems

Energy Procedia, 2017
The building sector is responsible for more than one third of the final energy consumption of societies and produces the largest amount of greenhouse gas emissions of all sectors. This is due to the utilisation of combustion processes of mainly fossil fuels to satisfy the heating demand of the building stock. Low temperature district heating (LTDH) can
Schmidt, Dietrich, Kallert, Anna, Blesl, Markus, Svendsen, Svend, Li, Hongwei, Nord, Natasa, Sipilä, Kari   +7 more
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Flexible and Highly Sensitive Humidity Sensor Based on Sandwich-Like Ag/Fe₃O₄ Nanowires Composite for Multiple Dynamic Monitoring

Nanomaterials, 2019
Functional textiles with unique functions, including free cutting, embroidery and changeable shape, will be attractive for smart wear of human beings. Herein, we fabricated a sandwich-like humidity sensor made from silver coated one-dimensional magnetite
Maojiang Zhang, Minglei Wang, Mingxing Zhang, Long Qiu, Yinjie Liu, Wenli Zhang, Yumei Zhang, Jiangtao Hu, Guozhong Wu   +8 more
doaj   +1 more source

Planning for a sustainable city region? Regional district heating in Stockholm [PDF]

, 2010
Stockholm is by far the largest city in Sweden and it is also the only region with legislated regional planning. Since the region has the highest and most dense population, regional cooperation is important in many aspects, for example by finding ...
Magnusson, Dick
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Energy efficiency facets: innovative district cooling systems

Entrepreneurship and Sustainability Issues, 2017
Cooling demand in buildings is globally increasing, therefore developing more efficient cooling systems is important for the sustainability of European cities. Directive 2012/27/EU of the European Parliament and of the council on energy efficiency states: “Member States should carry out a comprehensive assessment of the potential for high-efficiency ...
Passerini, Francesco, Sterling, Raymond, Keane, Markus, Klobut, Krzysztof, Costa, Andrea   +5 more
openaire   +7 more sources