Results 71 to 80 of about 153,973 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A comparison of prosumer system configurations in district heating networks

Energy Reports, 2021
Prosumer-based district heating networks attract an increasing interest in energy research. There are numerous publications addressing the prosumer integration into district heating networks with a focus on grid side operation.
Daniel Zinsmeister, Thomas Licklederer, Franz Christange, Peter Tzscheutschler, Vedran S. Perić   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Economic comparison of low-temperature and ultra-low-temperature district heating for new building developments with low heat demand densities in Germany

International Journal of Sustainable Energy Planning and Management, 2018
District heating risks to lose competitiveness the lower the linear heat density of a district is. The distribution network needs to be highly efficient in order to ensure economic feasibility.
Isabelle Best
doaj   +1 more source

Survey of radiator temperatures in buildings supplied by district heating [PDF]

Energy, 2017
In order to maintain the competitiveness and improve the environmental performance of district heating in the future, it is essential to transition to lower operating temperatures than those of current third-generation district heating systems. Heat demands are expected to decrease as buildings become more energy efficient, and new types of heat ...
M. Jangsten, J. Kensby, J.-O. Dalenbäck, A. Trüschel   +3 more
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

UPDATED HEAT BALANCE OF SUPPLIED HEAT ENERGY BY THE DISTRICT HEATING SYSTEM

Energy Technologies & Resource Saving
District heating systems are significant energy consumers in Ukraine and globally. The current regulatory documents in Ukraine that define the methodology for calculating the heat balance of a district heating system and the value of standard heat losses do not take into account some hidden heat losses that affect the prospects for economic growth of ...
V.L. Zviahintsev, V.M. Kozin, O.V. Ivchenko   +2 more
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Low temperature district heating based on low temperature geothermal heat (30 oC)

, 2021
A comparative study for a representative case district in the Netherlands with around 2500 dwellings has been executed with the purpose of identifying the best solution for a Low Temperature District Heating (LTDH) with Low Temperature Geothermal Heat ...
Knepper, S. (author), Infante Ferreira, C.A. (author), Pothof, I.W.M. (author), Itard, L.C.M. (author)   +3 more
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