Results 101 to 110 of about 20,269,821 (343)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The Impact of Optimal Demand Response Control and Thermal Energy Storage on a District Heating System

Energies, 2019
Demand response has been studied in district heating connected buildings since the rollout of smart, communicating devices has made it cost-effective to control buildings’ energy consumption externally.
Sonja Salo, A. Hast, J. Jokisalo, R. Kosonen, S. Syri, Janne Hirvonen, Kristian Martin   +6 more
semanticscholar   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Possibilities of applying a low-temperature centralized heat supply network in a multi-apartment building district

Mokslas: Lietuvos Ateitis
Lithuania‘s district heating (DH) network tends to maintain high heat transfer temperatures, which limit the efficiency of the system. The aim of this study is to assess the impact of DH and reduced heat transfer temperature in the building on space ...
Edita Rugieniūtė, Juozas Bielskus
doaj   +1 more source

A method of determining the thermal power demand of buildings connected to the district heating system with usage of heat accumulation

E3S Web of Conferences, 2017
The paper presents a new method of determining the thermal power demand of buildings connected to the district heating system, which included the actual heat demand and the possibility of balancing the thermal power using the thermal storage capacity of ...
Turski Michał, Sekret Robert
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

A Comparison of Different District Integration for a Distributed Generation System for Heating and Cooling in an Urban Area

Applied Sciences, 2019
The paper proposes a comparison of different district integration options for a distributed generation system for heating and cooling in an urban area. The system considered includes several production units located close to the users, a central unit and
Melchiorre Casisi, Dario Buoro, Piero Pinamonti, Mauro Reini   +3 more
doaj   +1 more source

Optimal operation of novel hybrid district heating system driven by central and distributed variable speed pumps

Energy Conversion and Management, 2019
The district heating system with distributed variable speed pumps can provide substantial energy savings, compared with the district heating system with conventional central circulating pump.
E. Gong, Na Wang, Shi-jun You, Ya-Ran Wang, Huan Zhang, Shen Wei   +5 more
semanticscholar   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Computational comparison of a novel decentralized photovoltaic district heating system against three optimized solar district systems

Energy Conversion and Management, 2019
Climate change is one of the biggest challenges at the present time, and to tackle such issue, solar energy and efficient buildings, in general, can be used.
H. ur Rehman, Janne Hirvonen, R. Kosonen, Si-Ren Kai   +3 more
semanticscholar   +1 more source