Results 51 to 60 of about 17,326 (266)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Analysis of the Methodology to Obtain Several Key Indicators Performance (KIP), by Energy Retrofitting of the Actual Building to the District Heating Fuelled by Biomass, Focusing on nZEB Goal: Case of Study

open access: yesEnergies, 2018
In order to achieve the objectives of the European 20/20/20 strategy, and to obtain a greater energy efficiency, integration of renewable energies and the reduction of carbon emissions, a District Heating (DH) system has been designed by the University ...
Rosaura Castrillón Mendoza   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Economic Analysis of Heat Distribution Concepts for a Small Solar District Heating System

open access: yesEnergies, 2022
One challenge in today’s district heating systems is the relatively high distribution heat loss. Lowering distribution temperatures is one way to reduce operational costs resulting from high heat losses, while changing the distribution system from steel ...
Martin Andersen   +2 more
doaj   +1 more source

The Green District Heating System

open access: yes, 2016
How is it possible to meet the government's 2035-goals whilst continuously supplying district heating in Denmark at low costs and at a high security of supply? This semester project analyses the possibilities of replacing the in-renewable heat production from the coal-fired CHP production unit FV07 at Fynsværket, with large industrial heat pumps.
Gjøl, Mathias   +5 more
openaire   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Framework for the Automated Identification of Possible District Heating Separations to Utilise Present Heat Sources Based on Existing Network Topology

open access: yesEnergies, 2022
The ambitious climate targets of the European Union emphasise the necessity to reduce carbon dioxide emissions in the building sector. Therefore, various sustainable heat sources should be used in existing district heating systems to cover the heat ...
Jan Stock, André Xhonneux, Dirk Müller
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

A Review of Existing Hybrid District Heating Substations and Their Application Potential

open access: yesEnergies
Decentralized renewable energy sources will become fundamental to future energy systems. The energy transition toward decentralized energy sources creates opportunities and challenges for district heating companies.
Michał Żurawski   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

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