Results 51 to 60 of about 26,889 (312)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Development of a user-friendly mobile app for the national level promotion of the 4th generation district heating

International Journal of Sustainable Energy Planning and Management, 2019
The consumers are considered to play one of the most significant roles in the district heating transition process towards the 4th generation.  Unfortunately, the lack of information and widespread consumer ignorance of interconnections and dependencies ...
Anna Volkova, Eduard Latõšov, Vladislav Mašatin, Andres Siirde   +3 more
doaj   +1 more source

Optimal Design of District Heating Networks with Distributed Thermal Energy Storages – Method and Case Study

International Journal of Sustainable Energy Planning and Management, 2021
District heating systems have a great potential for supporting the energy transition towards a renewa-ble energy system, and could also be an option in less dense populated urban districts and rural communities with a medium heat density. In these cases,
Johannes Röder, Benedikt Meyer, Uwe Krien, Joris Zimmermann, Torben Stührmann, Edwin Zondervan   +5 more
doaj   +1 more source

Integration of solar thermal systems in existing district heating systems [PDF]

Energy, 2016
Modem district heating (DH) networks are usually operated with a changing flow temperature to cover the heat load of the supply area, depending on the outside temperature. Due to the minimum temperature requirements of individual customers, DH networks also need to operate during the summer months. During this time, the load on the system is relatively
C. Winterscheid, S. Holler, J.-O. Dalenbäck   +2 more
openaire   +1 more source

Thermoeconomics as a tool for the design and analysis of energy savings initiatives in buildings connected to district heating networks [PDF]

, 2012
District Heating (DH) is a rational way to supply heat to buildings in urban areas. This is expected to play an important role in future energy scenarios, mainly because of the possibility to recover waste heat and to integrate renewable energy sources ...
Kona Albana, Verda, Vittorio, KONA, ALBANA   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Design and Performance Comparison of District Heating Systems in Milan and Riga

Environmental and Climate Technologies
The work proposes a comparison between three heating configurations covering the demand of a new settlement: 1) centralized district heating system (DHC); 2) 5th generation district heating & cooling system (5GDHC) and 3) individual home heating and ...
Brumana Giovanni, Bazbauers Gatis, Franchini Giuseppe, Ghirardi Elisa, Rieksta Madara   +4 more
doaj   +1 more source

Environmental Impact of District Heating System Retrofitting

Atmosphere, 2021
Retrofitting of district heating systems is a comprehensive process which covers all stages of district heating (DH) systems: production, distribution and consumption.
Aleksandrs Zajacs, Anatolijs Borodinecs, Nikolai Vatin   +2 more
doaj   +1 more source