Results 111 to 120 of about 920,121 (365)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dexamethasone induces sleep disturbance in a dose-dependent manner in mice
, 2023 Tomonobu Kato
openalex +1 more source
Seagrasses and seagrass habitats in Pacific small island developing states: Potential loss of benefits via human disturbance and climate change [PDF]
, 2020 Gilianne D. Brodie +4 more
openalex +1 more source
FireWildfire risk increases following non-fire disturbance events, but this relationship is not always linear or cumulative, and previous studies are not consistent in differentiating between disturbance loops versus cascades.
Leonardos Leonardos +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Disturbance and temporal variability in invertebrate assemblages in two South African rivers
, 2009 Includes abstract.This thesis presents an examination of the relationship between floods as disturbances, the disturbance regime and the temporal dynamics of invertebrate assemblages, over the short term and at intra- and inter-annual time scales in the ...
Ractliffe, Sylvia Georgiana
core
From species to communities : the signature of recreational use on a tropical river ecosystem [PDF]
, 2015 This work was funded by an ERC grant (BIOTIME 250189). A. E. M. thanks the Royal Society and M. D. thanks the Scottish Funding Council (MASTS HR09011) for support.Disturbance can impact natural communities in multiple ways.
Anne E. Magurran (7159652) +9 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source