Results 91 to 100 of about 1,788,937 (345)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Universal Uncertainty Principle in the Measurement Operator Formalism

, 2005
Heisenberg's uncertainty principle has been understood to set a limitation on measurements; however, the long-standing mathematical formulation established by Heisenberg, Kennard, and Robertson does not allow such an interpretation.
Arthurs E, Braginsky V B, Masanao Ozawa, Nakano H, Nielsen M A, Ozawa M, Ozawa M, Ozawa M, Ozawa M, Schrödinger E, von Neumann J, von Neumann J   +11 more
core   +1 more source

Senescent trees stabilize aboveground wood net primary production immediately after disturbance [PDF]

, 2020
In the United States, forests sequester 17% of national carbon (C) emissions annually (UGCRP, 2018), however shifting forest disturbances threaten the stability of this essential C sink.
Grigri, Maxim S
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Information-disturbance tradeoff in quantum measurements

, 2005
We present a simple information-disturbance tradeoff relation valid for any general measurement apparatus: The disturbance between input and output states is lower bounded by the information the apparatus provides in distinguishing these two states ...
A. Peres, C. W. Helstrom, K. Kraus, Lorenzo Maccone   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Trajectory Tracking and Formation Control of Mobile Robots Using Fuzzy Logic Controller with Obstacle Avoidance [PDF]

AUT Journal of Electrical Engineering
In various industries, the coordinated movements of mobile robots in triangular formations hold promise for enhancing efficiency and safety. This study investigates trajectory tracking and formation control using two distinct methodologies: the PID ...
Seyedeh Mahsa Zakipour Bahambari, Saeed Khankalantary   +1 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Environmental education during the COVID-19 pandemic: lessons from Ontario, Canada

Frontiers in Education
This study investigates the integration of place-based environmental education (PBEE) during emergency remote education (ERE) and in-person teaching, considering the implications of COVID-19.
Andrew A. Millward, Andrew A. Millward, Inga Borisenoka, Inga Borisenoka, Nickesh Bhagat, Gregory T. O. LeBreton   +5 more
doaj   +1 more source