Results 71 to 80 of about 576,419 (267)

Development and temporal validation of an interpretable prediction model for delayed diagnosis of benign paroxysmal positional vertigo: a retrospective study from Beijing, China

Preventive Medicine Reports
Objective: To develop and validate an interpretable prediction model for delayed diagnosis of benign paroxysmal positional vertigo (BPPV). Methods: This retrospective study included 10,422 BPPV patients between July 2020 and June 2024 in Beijing, China ...
Yanping Tong, Hongyan Li, Xue Xia, Yan Wang, Yu Cui, Xiaolin Wu, Yi Ju   +6 more
doaj   +1 more source

Trajectory Tracking and Formation Control of Mobile Robots Using Fuzzy Logic Controller with Obstacle Avoidance [PDF]

AUT Journal of Electrical Engineering
In various industries, the coordinated movements of mobile robots in triangular formations hold promise for enhancing efficiency and safety. This study investigates trajectory tracking and formation control using two distinct methodologies: the PID ...
Seyedeh Mahsa Zakipour Bahambari, Saeed Khankalantary   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Corrigendum to “Connexin 43 dephosphorylation at serine 282 induces spontaneous arrhythmia and increases susceptibility to ischemia/reperfusion injury” [Heliyon 9 (5), May 2023 Article e15879]

Heliyon, 2023
Lulin Wu, Tianhui Jiang, Zhiping Fu, Luqi Wang, Hongjie You, Jingyi Xue, Dali Luo   +6 more
doaj   +1 more source

Environmental education during the COVID-19 pandemic: lessons from Ontario, Canada

Frontiers in Education
This study investigates the integration of place-based environmental education (PBEE) during emergency remote education (ERE) and in-person teaching, considering the implications of COVID-19.
Andrew A. Millward, Andrew A. Millward, Inga Borisenoka, Inga Borisenoka, Nickesh Bhagat, Gregory T. O. LeBreton   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Synthesis and Perspectives on Disturbance Interactions, and Forest Fire Risk and Fire Severity in Central Europe

Fire
Wildfire risk increases following non-fire disturbance events, but this relationship is not always linear or cumulative, and previous studies are not consistent in differentiating between disturbance loops versus cascades.
Leonardos Leonardos, Anne Gnilke, Tanja G. M. Sanders, Christopher Shatto, Catrin Stadelmann, Carl Beierkuhnlein, Anke Jentsch   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source