Results 121 to 130 of about 143,865 (293)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

An investigation of seasonal disturbance intensity on wetland grass belts of Nysvley Nature Reserve [PDF]

, 2019
MSc (Botany)Department of BotanyThe use of disturbance in the management of Savanna is a common rangeland practice in South Africa. A two-season trial was established in June 2016 and December 2016 to evaluate the effects of disturbance of different ...
Gelebe, Vhuhwavho
core  

Warning in the woods: Species-specific and functional responses of the understorey along a deer browsing intensity gradient in a mixed temperate forest in France

Ecological Indicators
Understanding and predicting responses of plant community diversity and ecosystem functioning to disturbance is essential to achieving forest conservation and management goals.
Xavier Lecomte, Christophe Baltzinger, Anders Mårell   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Factors characterizing a type and intensity of forest management/anthropogenic disturbance.

Factors characterizing a type and intensity of forest management/anthropogenic disturbance.
Jan Šebesta (18264758), Pavel Peška (18264764), Robert Hruban (18264761), Paul C. Rogers (5866196), Antonín Kusbach (18264755)   +4 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

The role of wetland vegetation and water connectivity in shaping waterbird populations under human disturbance

Ecological Indicators
The floodplain wetland of Poyang Lake, one of the largest stopover sites for overwintering waterbirds along the East Asian–Australasian Flyway, is experiencing rising human disturbance and rapid landscape changes.
Yirong Wan, Linling Tang, Xuejiao Hou, Hui Lin, Xiaobin Cai, Zihui Huang, Qiangqiang Xu, Yuhong He   +7 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Ecological response hides behind the species abundance distribution : Community response to low-intensity disturbance in managed grasslands

, 2017
Land-use and management are disturbance factors that have diverse effects on community composition and structure. In traditional rural grasslands, such as meadows and pastures, low-intensity management is maintained to enhance biodiversity.
Elo, Merja, Merja Elo, Komonen, Atte, Atte Komonen   +3 more
core   +1 more source