Results 141 to 150 of about 20,641 (189)

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

Advanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu   +16 more
wiley   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, EarlyView.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source

Highly Stretchable, Self‐Healable, and Conductive Gelatin Methacryloyl Hydrogel for Long‐Lasting Wearable Tactile Sensors

Advanced Science, EarlyView.
Gelatin methacryloyl hydrogel, which possesses high stretchability, tensile strength, toughness, and autonomous self‐healing capability at room temperature, is developed through the introduction of interpenetrating networks, hierarchical hydrogen bonds (weak and strong H‐bonds), and borate ester bonds.
Zhikang Li, Bin Wang, Jijian Lu, Yumeng Xue, Jiaxiang Wang, Boqing Jia, Gengyu Han, Yihe Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Kang Zhao, Min Li, Ping Yang, Dejiang Lu, Libo Zhao   +14 more
wiley   +1 more source

Mixed‐Dimensional Floating Gate Phototransistors for Mixed‐Modal In‐Sensor Reservoir Computing

Advanced Science, EarlyView.
Designing bio‐inspired multisensory neuromorphic devices holds significant importance for low‐power and high‐efficiency computing. Here, the authors introduce a floating‐gate phototransistor based on the mixed‐dimensional heterostructure of 0D‐CsPbBr3 QDs and 2D‐MoS2 few layers.
Weilun Ouyang, Qirui Zhang, Jiangang Chen, Xiao Luo, Xuemei Wang, Yingying Chen, Fan Yang, Qi Nie, Qing Liu, Fucai Liu   +9 more
wiley   +1 more source

Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

Advanced Science, EarlyView.
A Mn(II)‐catalyzed electrochemical method achieves site‐selective diazidation of dehydroalanine peptides with NaN₃. This radical relay process tolerates diverse functional groups, delivers high yields, and enables precise peptide modification, offering a powerful tool for bioconjugation and therapeutic development.
Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan   +5 more
wiley   +1 more source

Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity

Advanced Science, EarlyView.
This study introduces a mild photocatalytic strategy for synthesizing tunable α‐sulfide disulfides from readily available sulfides and bilateral disulfurating reagents. The method demonstrates a broad substrate scope across aromatic and aliphatic sulfides, with products exhibiting versatile reactivity in diverse electrophilic transformations and ...
Qingqiang Tian, Chuxia Wang, Bingrui Liu, Xiangwei Wu, Yahui Li   +4 more
wiley   +1 more source

Bandgap Engineering on UiO–66 Metal‐Organic Framework Derivatives for Solar‐Driven Seawater Desalination

Advanced Science, EarlyView.
This work presents a bandgap engineering strategy via linker modification to enhance the photothermal conversion efficiency of UiO–66 metal‐organic framework (MOF) derivatives, achieving a remarkable evaporation efficiency of 97.40% and an evaporation rate of 2.34 kg·m−2·h−1 for seawater desalination, thereby contributing to the advancement of ...
Qisheng Shao, Yutong Ding, Wenxian Liu, Jia Guan, Ge Meng, Tairong Kuang, Dingsheng Wang   +6 more
wiley   +1 more source