Advanced Science, EarlyView.This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong +8 more
wiley +1 more source
Investigating the Effect of Isoelectric Points on the Gas-Phase Stability of Native-like Proteins Analyzed in Positive- versus Negative-Ion Mode by IMS-MS. [PDF]
Anal ChemEdwards AN +3 more
europepmc +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
Phosphine-catalyzed β-C(sp<sup>3</sup>)-H functionalization of cyclic amines <i>via</i> a halogen based frustrated radical pairs approach. [PDF]
Chem SciXie Y +7 more
europepmc +1 more source
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Thiol-mediated uptake of phosphorothioate liposomes, visualized with fluorescent flippers. [PDF]
Chem SciBouffard J, Bayard F, Sakai N, Matile S.
europepmc +1 more source
High‐Performance Recycling Biobased Photopolymers for 3D Printing
Advanced Science, EarlyView.By using biobased phenols like eugenol, novel biobased photopolymers containing dissociative phenol‐carbamate bonds are designed for 3D printing. Meanwhile, a “mixed‐monomer assisted recycling” strategy is proposed to recycle the materials. The resulting materials not only achieve high‐performance and excellent chemical recyclability simultaneously ...
Hang Zhou +12 more
wiley +1 more source
Activation and Functionalization of Organic Disulfides by Bis(Perfluoroalkyl) Complexes of Nickel(II). [PDF]
OrganometallicsRavidas CMT, Cramer RE, Vicic DA.
europepmc +1 more source
The Polymers of Life: Exploring Cellular Function Through Polymer Concepts
Advanced Science, EarlyView.Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley +1 more source