Results 231 to 240 of about 24,702 (304)

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Grafting Cell-Penetrating Poly(disulfide)s to Substrates of Interest: Dynamic Covalent Bioconjugation for Traceless Delivery. [PDF]

Angew Chem Int Ed Engl
Cognet M, Renno G, Coelho F, Sakai N, Matile S.   +4 more
europepmc   +1 more source

Scalable MoS2/Si Photodiode Arrays From Roll‐to‐Roll Mechanical Exfoliation

Advanced Science, EarlyView.
A dry roll‐to‐roll route transforms mechanically exfoliated MoS2 flake networks into silicon‐integrated photodiode arrays. The MoS2/Si junctions generate photovoltaic output without applied bias, allowing illuminated pixels to locate light spots and reconstruct simple images.
Yigit Sozen, Thomas Pucher, Andres Castellanos‐Gomez   +2 more
wiley   +1 more source

Harnessing Cross-Linked Cysteine Scaffolds for Soft Tissue Engineering Applications. [PDF]

Polymers (Basel)
Mtetwa L, Marimuthu T, Mndlovu H, Sithole MN, Makatini MM, Choonara YE.   +5 more
europepmc   +1 more source

Gas Sensing With Aerogels: A Critical Review on Structure‐Property Correlations and Performance Optimization

Advanced Science, EarlyView.
With high specific surface area, and adjustable interface, aerogel provides a multi‐functional platform for gas sensing. This review systematically links structural parameters (specific surface area, pore size, heterojunctions) to sensing metrics (sensitivity, selectivity, stability), critically evaluates optimization strategies, and outlines future ...
Hao Guo, Linheng He, Qinxin Wang, Man Yuan, Shoutian Qiu, Wei Liu, Sheng Cui   +6 more
wiley   +1 more source

Pathogenesis of Osteoarthritis: Mechanisms of Action of Disulfidptosis and Targeted Therapeutic Strategies. [PDF]

Drug Des Devel Ther
Liang Y, Wang K, Yang C, Huang J, Huang Z, Chen Y.   +5 more
europepmc   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states. [PDF]

Blood Adv
Butera D, Pijning AE, Avery NG, Coxon CH, Metcalfe C, Mimoun A, Lacroix-Desmazes S, Spiegel PC, Hogg PJ.   +8 more
europepmc   +1 more source

Sulfur-containing sustainable polymers: synthetic pathways, degradation mechanisms, and multifunctional applications. [PDF]

Natl Sci Rev
Song H, Meng J, Jiang X.
europepmc   +1 more source

Differential reactivity of bacillithiol, mycothiol and glutathione with nitroxyl (HNO): Structural determinants and potential biological implications. [PDF]

Redox Biol
Zeng Y, Owens P, Xia Z, Dos Santos PC, King SB.   +4 more
europepmc   +1 more source