Results 231 to 240 of about 26,459 (307)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Investigating the Effect of Isoelectric Points on the Gas-Phase Stability of Native-like Proteins Analyzed in Positive- versus Negative-Ion Mode by IMS-MS. [PDF]

Anal Chem
Edwards AN, Bannon MG, Cordes MS, Gallagher ES.   +3 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Activation and Functionalization of Organic Disulfides by Bis(Perfluoroalkyl) Complexes of Nickel(II). [PDF]

Organometallics
Ravidas CMT, Cramer RE, Vicic DA.
europepmc   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Impact of Organo-Functionalization on the Light-Driven Hydrogen Evolution Reactivity of Molecular Molybdenum Sulfides. [PDF]

Chemistry
Jahn M, Kammerer L, Schleicher L, Meyer A, Puthanagady MS, Mengele AK, Rau S, Kupfer S, Dietzek-Ivanšić B, Streb C.   +9 more
europepmc   +1 more source

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Designing soft materials through synthetic morphogenesis. [PDF]

Nat Commun
Bortnikov EO, Paikar A, Zhigileva EA, Fomitskaya P, Ariel N, Diskin-Posner Y, Avram L, Sui XM, Skorb EV, Sütő I, Horváth D, Tóth Á, Semenov SN.   +12 more
europepmc   +1 more source

Understanding polysulfide evolution in wine: insights from accelerated ageing and real-time cellaring in different packaging. [PDF]

Food Chem X
Hou Y, Bekker MZ, Siebert TE, Kreitman GY, Jeffery DW.   +4 more
europepmc   +1 more source

Phosphine-catalyzed β-C(sp³)-H functionalization of cyclic amines <i>via</i> a halogen based frustrated radical pairs approach. [PDF]

Chem Sci
Xie Y, Meng X, Liu C, Tan J, Zhang X, Zhang Z, Dong S, Liang T.   +7 more
europepmc   +1 more source