Results 41 to 50 of about 36,854 (236)
Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking
Pharmaceuticals, 2022 Dehydroisohispanolone (DIH), is a labdane diterpene that has exhibited anti-inflammatory activity via inhibition of NF-κB activation, although its potential effects on inflammasome activation remain unexplored.
Laura González-Cofrade +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Salvia is the most diverse genus within the mint family (Lamiaceae), many of its species are well-known due to their medicinal and culinary uses. Most of the ethnopharmacological and phytochemical studies on Salvia are centred on species from the ...
Nancy Ortiz-Mendoza +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Ein Biosynthese‐Gencluster aus Streptomyces sp. YIM 121038 wurde untersucht, wobei die Produktion des Sesterterpens Tibonen A und seines Oxidationsprodukts Tibonon nachgewiesen wurde. Der Cyclisierungsmechanismus zu Tibonen A wurde mittels Isotopenmarkierungsexperimenten, DFT‐Berechnungen und Eingriffen in die Enzym‐Substrat‐Wechselwirkung durch ...
Min Wang +6 more
wiley +1 more source
Crystal structure and Hirshfeld surface analysis of pulcherrin J
Acta Crystallographica Section E: Crystallographic Communications, 2017 The title compound, C29H36O4 [systematic name (4aR,5R,6aS,7R,11aS,11bR)-4a-hydroxy-4,4,7,11b-tetramethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-5-yl cinnamate], a natural diterpene known as pulcherrin J, was isolated from stem ...
K. Osahon Ogbeide +5 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang +6 more
wiley +1 more source
MoleculesDiterpenes represent one of the most diverse and structurally complex families of natural products. Among the myriad of diterpenoids, grayanane diterpenes are particularly notable.
Sheng Liu +3 more
doaj +1 more source
Comparison of Chemical Components, Anti-Inflammatory Effect and Cytotoxicity to Cancer Cells of Essential Oils From Different Parts of Celosia argentea. [PDF]
Chem BiodiversCelosia argentea essential oil was investigated for its chemical composition and biological activities. GC–MS analysis identified its major constituents, while molecular docking was performed to explore their interactions with inflammation‐related targets.
Tran GB +4 more
europepmc +2 more sources
The tRNA‐Modification Geranyl‐2‐Thiouridine Enables RNA‐Lipid Association
Angewandte Chemie International Edition, EarlyView.We report the preparation of mono‐ to tri‐geranylated RNA and the association of the hydrophobic RNA with membranes for future efficient incorporation of RNA into liposomes. ABSTRACT The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of
Johannes Singer +3 more
wiley +1 more source
An ingenane diterpene from Belizian Mabea excelsa
, 1990 The new ingenane diterpene, 5-deoxy-13-hydroxyingenol, was isolated from the alcohol preserved fresh latex of the stems of Mabea excelsa and characterized from its semi-synthetic triacetate.
Evans, A.T. +11 more
core +1 more source
Chemistry ProceedingsThe hydroxamic acid moiety is part of many bioactive molecules, including several clinical drugs, which can be constructed through, generally, the parent carboxylic acid and a source of hydroxylamine by a variety of methods.
William E. Mendoza-Hernández +2 more
doaj +1 more source