Results 41 to 50 of about 22,446 (231)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Cassane diterpenoids from lonchocarpus laxiflorus [PDF]

, 2008
This article examines cassane diterpenoids from lonchocarpus ...
Gray, A.I., Igoli, J.O., Letzel, M.C., Nwaji, M.N., Onyiriuka, S.O.   +4 more
core  

Chemical and antimicrobial analyses of Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood, an endemic of the Western Balkan [PDF]

, 2017
A comprehensive study on essential oil and different solvent extracts of Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood (Lamiaceae) from Montenegro is reported. The gas chromatography-mass spectrometry analysis of the essential oil revealed
Božović, Mijat, Cipolla, Alessia, De Angelis, Massimiliano, Garzoli, Stefania, Oliva, Alessandra, Ragno, Rino, Tadić, Vanja, Vullo, Vincenzo   +7 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Biological Activity of Bicyclic and Tricyclic Diterpenoids from of Immediate Pharmacological and Pharmaceutical Interest

Natural Product Communications, 2011
Diterpenoids are a class of compounds that derive from the condensation of four isoprene units that leads to a wide variety of complex chemical structures, including acyclic bi-, tri-and tetra-cyclic compounds; in Salvia species, only bi-, tri-and tetra ...
Maria Carmela Bonito, Carla Cicala, Maria Carla Marcotullio, Francesco Maione, Nicola Mascolo   +4 more
doaj   +1 more source

Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Molecules, 2019
Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties.
Simon Remy, Marc Litaudon
doaj   +1 more source

A Synthetic View on Momilactones and Related 9β-H Pimarane Skeleton Diterpenoids

Frontiers in Chemistry, 2022
Allelochemicals are secondary metabolites produced from plants and used to prevent and control the invasion of other plants and microorganisms, with broad application prospects in crop protection.
Yue Zhang, Mengran Li, Qichang Liu, Jian Huang, Yang Chen   +4 more
doaj   +1 more source

Exploring variations in potential carbon and nitrogen mineralization in managed grasslands among the diversity of soils in North Carolina

Grassland Research, EarlyView.
Under steady–state conditions, potential nitrogen mineralization in soil under grasslands is closely tied to potential carbon mineralization. This study provides supporting evidence that field–specific nitrogen fertilizer recommendations could be indicated by using a simple and rapid analysis of soil–test biological activity.
Alan J. Franzluebbers
wiley   +1 more source

Sunlight-driven Environmental Benign Production of Bioactive Natural Products with Focus on Diterpenoids and the Pathways Involved in their Formation

CHIMIA, 2017
Diterpenoids are high value compounds characterized by high structural complexity. They constitute the largest class of specialized metabolites produced by plants.
Dan Luo, Birger Lindberg Møller, Irini Pateraki   +2 more
doaj   +1 more source

3,4-Seco-Isopimarane Diterpenes from the Twigs and Leaves of Isodon Flavidus

Molecules, 2022
Three isopimarane diterpenes [fladins B (1), C (2), and D (3)] were isolated from the twigs and leaves of Chinese folk medicine, Isodon flavidus. The chemical structures were determined by the analysis of the comprehensive spectroscopic data, and the ...
Wan-Fei Li, Zheng-Ming Liang, Chen-Liang Zhao, Nga Yi Tsang, Ji-Xin Li, Ya-Hua Liu, Kang He, Lu-Tai Pan, Lijun Rong, Juan Zou, Hong-Jie Zhang   +10 more
doaj   +1 more source