Mechanisms of Diuretic Resistance Study: design and rationale [PDF]
ESC Heart Failure, 2020 Introduction Diuretic resistance is a common complication impairing decongestion during hospitalization for acute decompensated heart failure (ADHF). The current understanding of diuretic resistance mechanisms in ADHF is based upon extrapolations from ...
Zachary L. Cox +10 more
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Role of Early Assesment of Diuresis and Natriuresis in Detecting In-Hospital Diuretic Resistance in Acute Heart Failure [PDF]
Frontiers in Physiology, 2022 Background and Purpose: European Guidelines recommend early evaluation of diuresis and natriuresis after the first administration of diuretic to identify patients with insufficient diuretic response during acute heart failure.
Belén García-Magallón +21 more
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Diuretic resistance and the role of albumin in congestive heart failure [PDF]
Drugs in Context, 2023 Diuresis with loop diuretics is the mainstay treatment for volume optimization in patients with congestive heart failure, in which perfusion and volume expansion play a crucial role.
Carol Fernandez Hazim +6 more
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The utility of urine biomarkers in diuretic resistance prediction in heart failure hospitalization [PDF]
ESC Heart FailureAims Loop diuretic resistance (LDR) in patients with heart failure hospitalization (HHF) is associated with worse clinical outcomes. The study aimed to assess the predictive ability of urine biomarkers for LDR in HHF.
Tomasz Imiela +7 more
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American Journal of Kidney Diseases, 2017 Diuretic resistance is defined as a failure to achieve the therapeutically desired reduction in edema despite a full dose of diuretic. The causes of diuretic resistance include poor adherence to drug therapy or dietary sodium restriction, pharmacokinetic issues, and compensatory increases in sodium reabsorption in nephron sites that are not blocked by ...
Ewout J Hoorn, David H Ellison
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Systems biology of diuretic resistance. [PDF]
J Clin Invest, 2015 Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that ...
Knepper MA.
europepmc +5 more sources
Diuretic resistance in cardiorenal syndrome: mechanisms, monitoring and phenotype-tailored management [PDF]
Frontiers in Cardiovascular MedicineCongestion drives most hospitalizations for acute and chronic heart failure (HF), reflecting the pivotal role of sodium and water retention in disease progression. Loop diuretics remain the first-line decongestive therapy, yet up to one-third of patients
Georgios Aletras +12 more
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Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure [PDF]
European Journal of Heart Failure, 2017 Francis P Wilson +2 more
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Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial. [PDF]
JACC Heart Fail, 2020 Cox ZL, Hung R, Lenihan DJ, Testani JM.
europepmc +4 more sources
Diuretic Resistance Associated With Heart Failure. [PDF]
Cureus, 2022 Fluid retention is common in patients with heart failure (HF) and diuretics are a major source of management and stabilization. Diuretic resistance (DR) is defined as a failure to achieve therapeutically desired congestion relief despite using an appropriate diuretic dose.
Shams E, Bonnice S, Mayrovitz HN.
europepmc +3 more sources