Diuretic Resistance Treated with Low-Dose Hydralazine: A Case Report and Review of the Literature [PDF]
Case Reports in Nephrology and Dialysis, 2021 We present a case of severe diuretic resistance and edema from acute cardiorenal syndrome complicating heart failure with preserved ejection fraction (HFpEF) and mild alcoholic liver disease.
Mohammed Alshehri, Christopher Wilcox
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Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure [PDF]
Reviews in Cardiovascular MedicineBackground: Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF).
Yipin Yu +7 more
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The utility of urine biomarkers in diuretic resistance prediction in heart failure hospitalization [PDF]
ESC Heart FailureAims Loop diuretic resistance (LDR) in patients with heart failure hospitalization (HHF) is associated with worse clinical outcomes. The study aimed to assess the predictive ability of urine biomarkers for LDR in HHF.
Tomasz Imiela +7 more
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Diuretic Resistance in Heart Failure. [PDF]
Curr Heart Fail Rep, 2019 Diuretic resistance (DR) occurs along a spectrum of relative severity and contributes to worsening of acute heart failure (AHF) during an inpatient stay. This review gives an overview of mechanisms of DR with a focus on loop diuretics and summarizes the current literature regarding the prognostic value of diuretic efficiency and predictors of ...
Gupta R, Testani J, Collins S.
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Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure [PDF]
European Journal of Heart Failure, 2017 Francis P Wilson +2 more
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Effectiveness of Zhuling decoction on diuretic resistance in patients with heart failure: a randomized, controlled trial. [PDF]
J Tradit Chin Med, 2022 Yunhu C, Lihua F, Tao Z, Xueqian L.
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Systems biology of diuretic resistance. [PDF]
J Clin Invest, 2015 Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that ...
Knepper MA.
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Integrating the BAN-ADHF diuretic resistance score into same day emergency care centres for heart failure management: a conceptual framework [PDF]
Frontiers in Cardiovascular MedicineEarly recognition of diuretic resistance is essential for preventing avoidable admissions and progression of acute decompensated heart failure. This Perspective synthesises current evidence and proposes a pragmatic, digitally enabled framework for ...
Dominic M. Alfonso, Dominic M. Alfonso
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Diuretic resistance in cardiorenal syndrome: mechanisms, monitoring and phenotype-tailored management [PDF]
Frontiers in Cardiovascular MedicineCongestion drives most hospitalizations for acute and chronic heart failure (HF), reflecting the pivotal role of sodium and water retention in disease progression. Loop diuretics remain the first-line decongestive therapy, yet up to one-third of patients
Georgios Aletras +12 more
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A 2018 overview of diuretic resistance in heart failure
Revista Portuguesa de Cardiologia, 2018 Heart failure is a disease with high direct and indirect costs. Current treatment includes drugs that alter disease progression and drugs that to improve symptoms.
Sofia Isabel Jardim +6 more
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