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Diuretic Resistance in Heart Failure
Cardiology in Review, 2020Decompensated heart failure accounts for approximately 1 million hospitalizations in the United States annually, and this number is expected to increase significantly in the near future. Diuretics provide the initial management in most patients with fluid overload.
Rubayat, Rahman +6 more
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Mineral and Electrolyte Metabolism, 1999
Resistance to diuretic action is frequently encountered in the clinical setting. This is best managed by systematically optimizing the pharmacodynamic-pharmacokinetic factors that may be involved. Important pharmacodynamic measures include improving the underlying disease state, restriction of salt intake, limiting the use of vasodilators which may ...
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Resistance to diuretic action is frequently encountered in the clinical setting. This is best managed by systematically optimizing the pharmacodynamic-pharmacokinetic factors that may be involved. Important pharmacodynamic measures include improving the underlying disease state, restriction of salt intake, limiting the use of vasodilators which may ...
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The Clinical Investigator, 1994
Diuretics act by decreasing sodium reabsorption via inhibition of the entry of luminal sodium into the tubular cell. The various nephron segments have different mechanisms of sodium entry, and it is this characteristic that determines the site at which the diuretic acts.
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Diuretics act by decreasing sodium reabsorption via inhibition of the entry of luminal sodium into the tubular cell. The various nephron segments have different mechanisms of sodium entry, and it is this characteristic that determines the site at which the diuretic acts.
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Diuretic resistance in heart failure
Current Heart Failure Reports, 2006The use of diuretics for the treatment of heart failure (HF) is ubiquitous in any basic HF medical regimen. Although initially these drugs clearly show benefit by relieving symptomatic episodes of decompensated HF, long-term use of these drugs can lead to a "diuretic-resistant" state and is associated with an increased risk of morbidity and mortality ...
Srinivas, Iyengar, William T, Abraham
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Archives of Internal Medicine, 1986
Hepatic sinusoidal hydrostatic-oncotic balance was measured in 25 patients with alcoholic liver disease and varying severity of sodium retention. Eight patients had diuretic-responsive ascites and 17 patients had diuretic-resistant ascites. Net "transfer pressure," the force theoretically favoring fluid transudation across the hepatic sinusoids, was ...
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Hepatic sinusoidal hydrostatic-oncotic balance was measured in 25 patients with alcoholic liver disease and varying severity of sodium retention. Eight patients had diuretic-responsive ascites and 17 patients had diuretic-resistant ascites. Net "transfer pressure," the force theoretically favoring fluid transudation across the hepatic sinusoids, was ...
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Journal of Cardiac Failure, 2014
Loop diuretics are a cornerstone of symptom management for nearly all patients with heart failure. Diuretic resistance is a clinical problem with similar presentation despite diverse and multiple etiologies. Although the exact incidence is not known, diuretic resistance occurs frequently and can increase the length of hospitalization.
Zachary L. Cox, Daniel J. Lenihan
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Loop diuretics are a cornerstone of symptom management for nearly all patients with heart failure. Diuretic resistance is a clinical problem with similar presentation despite diverse and multiple etiologies. Although the exact incidence is not known, diuretic resistance occurs frequently and can increase the length of hospitalization.
Zachary L. Cox, Daniel J. Lenihan
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Annals On Call - Diuretic Resistance
Annals of Internal Medicine, 2018In this episode of Annals On Call, Dr. Centor discusses diuretic resistance in patients with heart failure with Dr. Joel Topf.
Robert M. Centor, Joel M. Topf
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Drugs, 1981
Resistance to diuretics occurs frequently in clinical settings. Most attention to this phenomenon has been directed toward the pathophysiology of the disease state, with little focus on the pharmacology of the diuretics themselves. This review summarises the pathogenesis and emphasises the pharmacological determinants of response to diuretics ...
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Resistance to diuretics occurs frequently in clinical settings. Most attention to this phenomenon has been directed toward the pathophysiology of the disease state, with little focus on the pharmacology of the diuretics themselves. This review summarises the pathogenesis and emphasises the pharmacological determinants of response to diuretics ...
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Diuretic Resistance versus Adaptation
Annals of Internal Medicine, 1991To the Editors: Ellison (1), in his excellent study of diuretic resistance, does not consider its most common occurrence—the absence of diuresis with continued administration of a diuretic to a per...
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Loop diuretic resistance complicating acute heart failure
Heart Failure Reviews, 2019Acute heart failure hospitalizations complicated by diuretic resistance are associated with worse outcomes. Yet, quantification of the frequency and accompanying risk from loop diuretic resistance is limited by the absence of a comprehensive definition with universal clinical application.
Zachary L. Cox, Jeffrey M. Testani
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