Results 81 to 90 of about 53,487 (288)

Prevalence of prediabetes and undiagnosed diabetes in patients with HFpEF and HFrEF and associated clinical outcomes [PDF]

, 2017
Purpose: The prevalence and consequences of prediabetic dysglycemia and undiagnosed diabetes is unknown in patients with heart failure (HF) and preserved ejection fraction (HFpEF) and has not been compared to heart failure and reduced ejection ...
Christopher B. Granger, John J. V. McMurray, Karl Swedberg, Lars Køber, Marc A. Pfeffer, Matthew M. Y. Lee, null null, Pardeep S. Jhund, Salim Yusuf, Scott D. Solomon, Søren L. Kristensen   +10 more
core   +3 more sources

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]

, 2016
Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E, De Bruin, E, Downward, J, Heynen, GJJE, Hu, Y, Li, H, Liu, Z, Pardo, OE, Roy, R, Seckl, MJS, Smit, EF, Stokes, W, Tang, H, Wang, Y   +13 more
core   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Combination of thiazide and loop diuretics for the treatment of acute heart failure

Cardiologia Hungarica
Acute heart failure (AHF) is a serious condition with a high mortality rate. It is considered as the most common cause of unplanned hospitalizations in the elderly population. In 90% of all cases AHF presents with congestive symptoms, thus mostly treated
Krisztina Fekete, Róbert Halmosi, Tamás Habon   +2 more
doaj   +1 more source

Diuretic resistance in patients with chronic heart failure: mechanisms, prevention, and treatment

Бюллетень сибирской медицины, 2022
The authors analyzed the problem of diuretic resistance (DR) in patients with chronic heart failure (CHF). Most of the symptoms and signs of CHF are associated with hypervolemia and vascular congestion in the systemic and pulmonary circulation.
V. V. Kalyuzhin, A. T. Teplyakov, I. D. Bespalova, E. V. Kalyuzhina, N. N. Terentyeva, I. K. Livshits, V. L. Ostanko, E. V. Grakova, K. V. Kopeva, V. Yu. Usov, N. P. Garganeeva, Yu. V. Gorelova   +11 more
doaj   +1 more source

Mechanisms of hypertension during and after orthotopic liver transplantation in children [PDF]

, 1989
The aim of this study was to assess the hormonal alterations that may mediate the systemic hypertension that develops in patients during the perioperative period of orthotopic liver transplantation.
Akerstedt, Andrews, Ann Thompson, Arroyo, Bantle, Bantle, Baxter, Baylis, Bellet, Bernardi, Better, Bland, Bomzon, Bonjour, Borland, Busuttil, Cappuccio, Carlos Esquivel, Chrymko, Clement de Clety, Curtis, D. Ryan Cook, Demetrius Ellis, Epstein, Eskay, Filep, Floras, Gaillard, Gardner, Gartner, Gentile, Gerr, Glantz, Graystone, Henriksen, Hiatt, Januszewicz, Kimura, Kohno, Lau, Ledsome, Leslie, Loughran, Lustig, Mason, Minuk, Moss, Murrey, Nakai, Nicholls, Oaks, Ogawa, Palestine, Papadakis, Powell-Jackson, Ring-Larsen, Ring-Larsen, Rosanto, Salazar, Schacter, Seino, Shapiro, Skorecki, Starzl, Stephen Lawless, Task Force on Blood Pressure Control in Children, Thomas Starzl, Thompson, Vacanti, Voorhees, Weidle, Weidmann, Williams   +72 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Sodium chloride transport of normal and dietary enlarged rat cecum in vitro [PDF]

, 1998
Sodium chloride transport across isolated cecum mucosa was investigated in normal rats and rats with adaptive cecum growth induced by dietary polyethylene glycol (PEG). The normal cecum absorbed CI in excess of Na with a small short-circuit current (Isc).
Loeschke, Klaus, Schreiner, Josefine, Weber, Matthias   +2 more
core   +1 more source

Ultrafiltration in Diuretic-Resistant Cardiac Failure

Renal Failure, 1987
Ultrafiltration was performed in 13 patients with diuretic-resistant cardiac failure. All patients had severely distressing peripheral edema and ultrafiltration was successfully completed in 12 patients, all of whom sustained symptomatic improvement. The volume of fluid removed ranged from 3.7 to 23 L, mean 11.8 L.
I A, Simpson, K, Simpson, A P, Rae, J M, Boulton-Jones, M E, Allison, I, Hutton   +5 more
openaire   +2 more sources