Results 101 to 110 of about 167,304 (257)

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 12, Page 3252-3267, 15 June 2026.
What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Karen J. Scott, Emma J. West, Rebecca J. Brownlie, Fay Ismail, Christy Ralph, Thomas Heineman, Matt Coffey, Alan A. Melcher, Alison Taylor, Salvatore Papa, Adel Samson   +10 more
wiley   +1 more source

Vortices in the two-dimensional Simple Exclusion Process

, 2008
We show that the fluctuations of the partial current in two dimensional diffusive systems are dominated by vortices leading to a different scaling from the one predicted by the hydrodynamic large deviation theory.
B. Derrida, B. Derrida, C. Kipnis, C. Kipnis, C. Maes, D. Andrieux, D.J. Evans, D.J. Evans, F. Bonetto, G. Gallavotti, G. Gallavotti, H. Spohn, J. Kurchan, J.L. Lebowitz, Joel L. Lebowitz, L. Bertini, L. Bertini, L. Bertini, M. Donsker, S. Ciliberto, T. Bodineau, T. Bodineau, T. Bodineau, T. Bodineau   +23 more
core   +3 more sources

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Bridging research, policy, and practice: Advancing evidence‐informed approaches for dementia care and prevention: An expert review by the Health Policy Professional Interest Area from ISTAART

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract Bridging dementia research and policy remains a global challenge, with gaps in governance, capacity, data infrastructure, and contextual fit limiting the development and implementation of effective national dementia plans. To inform this issue, the Health Policy Professional Interest Area of the International Society to Advance Alzheimer's ...
Juliana Souza‐Talarico, Maria M. Pinzon, Jayalakshmi Viswanathan, Tuan Anh Nguye, Walter D. Dawson, Jay Lusk, Crystal Glover, Perlina Desai, Anna Shelander, Lesley E. Williamson, Dallas Seitz, Joseph M. Costello, Magdalena Pereyra, Yixuan Cheng, Sharon Naismith, Andrea Slachevsky, Lycia Tramujas Vasconcellos Neumann, Preeti Pushpalata Zanwar   +17 more
wiley   +1 more source

"Mise en Abyme" y parodia divezca en los epígrafes de The Buenos Aires Affair de Manuel Puig: Separación del amante.

Káñina, 2012
Este artículo intenta demostrar cómo los epígrafes de la novela The Buenos Aíres Affair de Manuel Puig establecen una "mise en abyme" entre las estrellas de cine que en ellos aparecen y las actuaciones de sus dos principales personajes los cuales son ...
Raimy Camacho Ramirez
doaj  

Co‐Designing a Digital Brain Health Intervention for Chinese Older Adults: A User‐Centred Approach

Australasian Journal on Ageing, Volume 45, Issue 2, June 2026.
ABSTRACT Objectives This study aimed to co‐design, with key stakeholders, a digital dementia risk reduction application (app) for Chinese older migrant adults and carers residing in Australia, and to address the challenges of this proposed intervention.
Joyce Siette, Siyao Cheng, Jed Montayre, Laura Dodds   +3 more
wiley   +1 more source

Nationwide emergence and spread of highly virulent PRRSV-2 mutants in Korea

Porcine Health Management
Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) continues to pose a major threat to global swine health. In South Korea, the co-circulation of endemic strains and repeated introductions of foreign variants has led to a complex viral ...
Seung-Chai Kim, Sang Chul Kang, Hwan-Ju Kim, Jonghyun Park, Hye-Ryung Kim, Choi-Kyu Park, Won-Il Kim   +6 more
doaj   +1 more source

Environmental Aspects in Price and Reimbursement Decisions of Medicines—A Scoping Review

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 6, June 2026.
ABSTRACT Environmental impacts of medicines are increasingly recognised but rarely embedded in their pricing and reimbursement (P&R) and related assessments. This scoping review mapped how environmental aspects, including antimicrobial resistance (AMR) stewardship, are or could be considered in P&R of medicines and identified challenges for their ...
Lasse Alajärvi, Mirella Miettinen, Johanna Timonen   +2 more
wiley   +1 more source

Application of direct inverse analogy method (DIVA) and viscous design optimization techniques [PDF]

A direct-inverse approach to the transonic design problem was presented in its initial state at the First International Conference on Inverse Design Concepts and Optimization in Engineering Sciences (ICIDES-1).
Forbrich, D., Greff, E., Schwarten, H.
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source