Results 121 to 130 of about 24,756 (268)
Advanced Science, EarlyView.VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho +6 more
wiley +1 more source
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
In Situ CO2‐Induced Hydrogels for Enhancing Carbon Sequestration in Saline Aquifers
Advanced Science, EarlyView.A novel integrated method that combines in situ CO2‐induced phase‐transition hydrogels formed by a C22‐tailed tertiary amine dispersion with tailored deep eutectic solvents to increase CO2 sequestration in saline aquifers. ABSTRACT Carbon sequestration in saline aquifers underpins global net‑zero emission goals, yet existing CO2 storage capacity ...
Fuchuan Liu +5 more
wiley +1 more source
Time Domains of Hypoxia Adaptation—Elephant Seals Stand Out Among Divers
Frontiers in Physiology, 2019 Michael S. Tift, Paul J. Ponganis
doaj +1 more source
Advanced Science, EarlyView.This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang +15 more
wiley +1 more source
MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation
Advanced Science, EarlyView.We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui +18 more
wiley +1 more source
Advanced Science, EarlyView.In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng +17 more
wiley +1 more source
Hydrogen Production from Ammonia Electrochemical Cracking
Advanced Science, EarlyView.NH3 electrochemical cracking (e‐cracking) is a complementary technique to centralized thermal cracking for releasing H2 from NH3. In this article, we review recent advances in catalyst development for these cracking techniques and conduct a techno‐economic analysis (TEA) to evaluate the economic feasibility of e‐cracking.
Yike Ye +4 more
wiley +1 more source
Sulfide‐Based Electrolytes for All‐Solid‐State Sodium Batteries
Advanced Energy Materials, EarlyView.This review covers the structural features and synthesis strategies of sulfide‐based solid electrolytes, as well as critical challenges related to conductivity, interfacial and moisture stability, and scaling‐up for practical application in Sodium‐based All Solid‐State Batteries.
Han Yang +6 more
wiley +1 more source