Results 151 to 160 of about 860,939 (358)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A General Divergence Measure for Monotonic Functions and Applications in Information Theory

, 2004
A general divergence measure for monotonic functions is introduced. Its connections with the f−divergence for convex functions are explored.
Dragomir, Sever S
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Integración económica y desequilibrios territoriales en la Unión Europea

EURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales, 2004
Ante la falta de acuerdo de las teorías económicas sobre los efectos territoriales de los procesos de integración económica, este artículo analiza desde una base empírica el impacto de la integración económica europea sobre los desequilibrios regionales.
Andrés Rodríguez-Pose, George Petrakos
doaj  

Divergence measures based on the Shannon entropy

IEEE Transactions on Information Theory, 1991
Jianhua Lin
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dynamic Modeling and Its Impact on Estimation Accuracy for GPS Navigation Filters

Sensors
This study addresses the divergence issues in GPS navigation systems caused by inaccuracies in dynamic modeling and explores solutions using the extended Kalman filter (EKF). Since algorithms such as the Kalman filter (KF) and EKF rely on assumed process
Dah-Jing Jwo, Ta-Shun Cho, Birhanu Ayalew Demssie   +2 more
doaj   +1 more source

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times.

Molecular biology and evolution, 2017
Sudhir Kumar, G. Stecher, Michael Suleski, S. Hedges   +3 more
semanticscholar   +1 more source

Divergence-Free Multiwavelets

, 1998
. In this paper we construct IR n -valued biorthogonal, compactly supported multiwavelet families such that one of the biorthogonal pairs consists of divergence-free vector wavelets.
Divergence-free Multiwavelets, Maria C. Pereyra, Peter R. Massopust, Joseph Lakey   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source