Results 151 to 160 of about 2,518,110 (330)
Objective Bayes estimation and hypothesis testing : the reference-intrinsic approach [PDF]
, 2005 Conventional frequentist solutions to point estimation and hypothesis testing typically need ad hoc modifications when dealing with non-regular models, and may prove to be misleading.
Juárez, Miguel A.
core
On Dynamic Cumulative Residual Pearson
IEEE AccessThe divergence measure plays a central role in quantifying the dissimilarity between probability distributions and are widely used in information theory, statistics, reliability modeling and machine learning. The Kullback-Leibler and Pearson $\chi ^{2}$
P. Akila, Rajesh Moharana
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Innovation performance and R&D expenditures in Western European regions: Divergence or convergence? [PDF]
, 2018 Although Western Europe is a global leader in innovation activities among the OECD countries, these activities are not distributed evenly across NUTS 2 regions.
Halásková, Martina, Bednář, Pavel
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Application of Phi-divergence to Estimation in Continuous Families
, 2007 Application of Phi-divergence to Estimation in Continuous ...
Vajda, Igor
core
Generalized M-Estimation-Based Framework for Robust Guidance Information Extraction
EntropyThis study tackles state estimation challenges in guidance information extraction. These challenges arise from non-Gaussian noise. We propose a robust framework to address them.
Jiawei Ren +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source