Results 131 to 140 of about 2,518,110 (330)
Analysing Growth and Distribution Dynamics - Isolating Divergence Factors [PDF]
This paper analyses the factors driving convergence and divergence processes in the growth dynamics of European urban regions over the period 1978 to 1994. To achieve this, we develop a two-stage procedure. First, viewing growth of real GDP per capita as
Paul Cheshire, Stefano Magrini
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Genome-wide Estimation of Evolutionary Distance and Phylogenetic Analysis of Homologous Genes
Bio-Protocol, 2018 Homologous genes, including paralogs and orthologs, are genes that share sequence homologies within or between different species. Homologous genes originate from a common origin through speciation, genetic duplication or horizontal gene transfer ...
Meixia Zhao +3 more
doaj +1 more source
, 2015 Smith, V.S.* Did dinosaurs have lice? estimating rates of diversification in parasitic lice. Biostatistics workshop (Bayesian and likelihood inference of phylogeny) with John Huelsenbeck, Fred Ronquist, Dave Swofford, and Jeff Thorne. University of Illinois at Urbana-Champaign, USA. May 22-31, 2005.
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
On maximum likelihood estimation and divergence minimization
, 2002 The probabilistic inference (PI) problem was reformulated as the divergence minimization (DM) problem, having a natural geometrical interpretation. The DM problem was solved using an iterative algorithm.
Chan, T.H.L., Yeung, R.
core +1 more source
Refining Jensen–Mercer inequality and its applications in probability and statistics
Journal of Inequalities and ApplicationsThis paper focuses on refining the Jensen–Mercer inequality and extending its applications to various important inequalities, including Hölder’s, Ky Fan, and AM-GM inequalities.
Rabia Bibi, Sajid Ali
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
BMC Bioinformatics, 2006 Background Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, divergences and tools, and further how this variation impacts specific ...
Iyer Venky N +3 more
doaj +1 more source