Results 81 to 90 of about 55,988 (263)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

منهج الإمام البزدوي في تناول القضايا اللغوية من خلال كتاب كنز الوصول إلى علم الأصول "دلالة المشترك اللفظي" نموذجاً [PDF]

Maǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ Būrsaʿīd
من البديهي أن الدليل الشرعي هو المحور الذي يدور حوله العمل ؛ لمعرفة مراد المشرع سبحانه وتعالى ونظراً؛ لأن التشريع جاء باللغة العربية فلابد من معرفة دلالات الألفاظ والمعاني الدالة على الأحكام الشرعية .
محمد محمد السايس
doaj   +1 more source

Linguistic advergence and divergence in north-western Catalan: A dialectometric investigation of dialect leveling and border effects

Literary and Linguistic Computing, 2013
This article investigates several linguistic changes which are ongoing in north-western Catalan using a contemporary corpus. We take advantage of a range of dialectometric methods that allow us to calculate and analyse the linguistic distance between varieties in apparent time from an aggregate perspective. Specifically, we pay attention to the process
Valls, Esteve, Wieling, Martijn, Nerbonne, John   +2 more
openaire   +3 more sources

NEXUS Network: Connecting the Preceding and the Following in Dialogue Generation

, 2018
Sequence-to-Sequence (seq2seq) models have become overwhelmingly popular in building end-to-end trainable dialogue systems. Though highly efficient in learning the backbone of human-computer communications, they suffer from the problem of strongly ...
Klakow, Dietrich, Li, Wenjie, Shen, Xiaoyu, Su, Hui   +3 more
core   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

An evaluation of estimative uncertainty in large language models

npj Complexity
Words of estimative probability (WEPs), such as “maybe” or “probably not” are ubiquitous in natural language for communicating estimative uncertainty. In linguistics, WEPs are hypothesized to have special (probabilistic) semantics, and their calibration ...
Zhisheng Tang, Ke Shen, Mayank Kejriwal
doaj   +1 more source

Tracing the Linguistic Roots of Malay and Batak Languages in Sumatra Island: A Historical Comparative Study

Okara: Jurnal Bahasa dan Sastra
Previous research in comparative historical linguistics has traditionally focused on languages within a single region, overlooking cognate languages in other areas.
Riska Meliana, Manna Maria Sopiana Manalu, Sulis Triyono   +2 more
doaj   +1 more source

Information Structure of Language and Its Semantic Representation Based on Lambercht’s Theory; A Study of the Translation of the Crisumstantail Clause in Surah Al-Baqarah [PDF]

پژوهش‌های ترجمه در زبان و ادبیات عربی
In contemporary linguistics, the structure of information in language is considered an important topic. It scrutinizes the relationship between sentence structures and the language or extralinguistic contexts in which they function.
Peyman Karimi, Mahmood Shahbazi, Sayed Abolfazl Sajady, Ghasem Azizi Morad   +3 more
doaj   +1 more source

Linguistic Choices for Literary Dialectics: A Coming Together of Divergent Entities

European Scientific Journal, ESJ, 2016
Literature involves the manipulation of language for creative purposes and the discipline which fosters this synergic relationship between literature and language is termed stylistics. The purpose of this article is to show how it is possible to bridge the divide between language and literature by using the analytical techniques available within this ...
Sabitha S. R. Najeeb, Manar AlDawood
openaire   +2 more sources

Goal-oriented Dialogue Policy Learning from Failures

, 2018
Reinforcement learning methods have been used for learning dialogue policies. However, learning an effective dialogue policy frequently requires prohibitively many conversations. This is partly because of the sparse rewards in dialogues, and the very few
Chen, Xiaoping, Lu, Keting, Zhang, Shiqi
core   +1 more source